KIRREL3/NEPH2 Protein, Mouse (HEK293, His)

The KIRREL3/NEPH2 protein emerges as a pivotal synaptic adhesion molecule essential for the precise formation of target-specific synapses, particularly notable at hippocampal mossy fiber synapses. Its significance extends to the orchestration of mossy fiber filopodia, critical synaptic structures linking dentate granule and GABA neurons. Functionally, KIRREL3/NEPH2 likely serves as a homophilic adhesion molecule, fostering trans-cellular interactions and playing a key role in stabilizing mossy fiber filipodia contacts, thereby facilitating subsequent synapse formation. Beyond the hippocampus, KIRREL3/NEPH2 is vital for the coalescence of vomeronasal sensory neuron axons. Moreover, it may play a role in the hematopoietic supportive capacity of stroma cells, with its secreted extracellular domain directly supporting hematopoietic stem cells. Functioning as a homodimer, KIRREL3/NEPH2 mediates homophilic interactions crucial for promoting cell adhesion. Additionally, it engages in a spectrum of protein-protein interactions, including the formation of heterodimers with NPHS1, interactions with NPHS2/podocin, CASK, MAP1B, MYO16, ATP1B1, SHMT2, and UFC1, underscoring its multifaceted and integral role in diverse cellular processes.