Kirrel3 - kirre like nephrin family adhesion molecule 3 Gene

Also Known as SST4; NEPH2; mKIAA1867; 1500010O20Rik; 2900036G11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67703

Summary

Predicted to enable cell adhesion molecule binding activity. Involved in hemopoiesis; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Acts upstream of or within glomerulus morphogenesis; inter-male aggressive behavior; and nervous system development. Located in several cellular components, including axon; dendritic shaft; and extracellular region. Is integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; glomerular tuft; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 4. Orthologous to human KIRREL3 (kirre like nephrin family adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Kirrel3 Products (5)

mRNA Protein Name
NM_001190911.1 NP_001177840.1 kin of IRRE-like protein 3 isoform A precursor
NM_001190912.1 NP_001177841.1 kin of IRRE-like protein 3 isoform C precursor
NM_001190913.1 NP_001177842.1 kin of IRRE-like protein 3 isoform D precursor
NM_001190914.1 NP_001177843.1 kin of IRRE-like protein 3 isoform E
NM_026324.3 NP_080600.1 kin of IRRE-like protein 3 isoform B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16874800 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glomerulus morphogenesis IMP
IMP: Inferred from mutant phenotype
23637329 MGI
involved in hemopoiesis IDA
IDA: Inferred from direct assay
12665856 MGI
involved in hippocampus development IMP
IMP: Inferred from mutant phenotype
26575286 MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
26575286 MGI
acts upstream of or within inter-male aggressive behavior IMP
IMP: Inferred from mutant phenotype
23637329 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
21241806 MGI
acts upstream of or within neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
23637329 MGI
acts upstream of or within principal sensory nucleus of trigeminal nerve development IMP
IMP: Inferred from mutant phenotype
21241806 MGI
involved in synapse assembly IDA
IDA: Inferred from direct assay
26575286 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16874800 MGI
located in dendrite IDA
IDA: Inferred from direct assay
26575286 MGI
located in dendritic shaft IDA
IDA: Inferred from direct assay
16874800 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
12665856 MGI
located in membrane IDA
IDA: Inferred from direct assay
12665856 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12665856 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kin of IRRE-like protein 3

  • X kin of IRRE like 3

  • kin of IRRE like 3

  • kin of irregular chiasm-like protein 3

  • membrane protein mKirre

  • nephrin-like protein 2

Recombinant Kirrel3 Proteins

Cat. No. Product Name Accession Purity
HY-P77045 KIRREL3/NEPH2 Protein, Mouse (HEK293, His) Q8BR86 (L22-A535) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07314 KIRREL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18723 Kirrel3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25210 Kirrel3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kirrel3 NCBI NCBI:84623