LAIR2 Protein, Human (HEK293, His-Avi)

Leukocyte-associated immunoglobulin-like receptor 2 is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived LAIR2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

Leukocyte-associated immunoglobulin-like receptor 2 is a member of the immunoglobulin superfamily. Leukocyte-associated immunoglobulin-like receptor 2 is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. Leukocyte-associated immunoglobulin-like receptor 2 maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily^[1][2][3].

Human

HEK293

C-Avi;C-8*His

Q6ISS4-1 (Q22-P152)

3904  [NCBI]

Full Length of Isoform-1 Mature Protein

QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAP

Approximately 20-25 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Liu J, et al. Human-specific LAIR2 contributes to the high invasiveness of human extravillous trophoblast cells. Reprod Biol. 2019 Sep;19(3):287-292.  [Content Brief]

  [2]. Olde Nordkamp MJ,et al. Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2. J Innate Immun. 2014;6(3):284-92.  [Content Brief]

  [3]. Founds SA, et al. LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion. Placenta. 2013 Mar;34(3):248-55.  [Content Brief]