LAIR2 - leukocyte associated immunoglobulin like receptor 2 Gene
Also Known as CD306
Species: Homo sapiens
About LAIR2
This gene has 4 transcripts (splice variants), 1 gene allele, 215 orthologues and 25 paralogues. Biased expression in placenta (RPKM 4.7), lymph node (RPKM 0.9) and 3 other tissues.
Summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
LAIR2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_002288.6 | NP_002279.2 | leukocyte-associated immunoglobulin-like receptor 2 isoform a precursor |
| NM_021270.5 | NP_067154.1 | leukocyte-associated immunoglobulin-like receptor 2 isoform b precursor |
LAIR2 Protein Structure
Ig_2: Immunoglobulin domain (29 - 120)
- 0
- 100
- 152 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
leukocyte-associated immunoglobulin-like receptor 2 |
|
LAIR2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
LAIR2 | Q6ISS4 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | LCN2 | Homo sapiens | P80188 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | LCN2 | Homo sapiens | P80188 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | SGTA | Homo sapiens | O43765 | 25416956 | |
|
Intra
|
LAIR2 | Q6ISS4 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | SGTA | Homo sapiens | O43765 | 25416956 | |
|
Intra
|
LAIR2 | Q6ISS4 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | UBQLN1 | Homo sapiens | Q9UMX0 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | EMILIN1 | Homo sapiens | Q9Y6C2 | 25416956 | |
|
Intra
|
LAIR2 | Q6ISS4 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
LAIR2 | Q6ISS4 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Recombinant LAIR2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72391 | LAIR2 Protein, Human (Biotinylated, HEK293, Avi-His) | Q6ISS4-1 (Q22-P152) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72527 | LAIR2 Protein, Human (HEK293, His) | Q6ISS4-1 (Q22-P152) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77050 | LAIR2 Protein, Human (HEK293) | Q6ISS4-1 (Q22-P152) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78323 | LAIR2 Protein, Human (HEK293, His-Avi) | Q6ISS4-1 (Q22-P152) | ≥ 95%, as determined by Bis-Tris PAGE. |