NOTCH1 Protein, Mouse (sf9, His)

NOTCH1 Protein functions as a receptor for membrane-bound ligands, including Jagged-1 (JAG1), Jagged-2 (JAG2), and Delta-1 (DLL1), playing a crucial role in cell-fate determination. Upon ligand activation, the released Notch intracellular domain (NICD) forms a transcriptional activator complex with RBPJ/RBPSUH, activating genes in the enhancer of split locus and influencing differentiation, proliferation, and apoptosis. NOTCH1 is involved in angiogenesis, negatively regulating endothelial cell proliferation, migration, and angiogenic sprouting. It contributes to thymic maturation of CD4(+) and CD8(+) cells, follicular differentiation, and possibly cell fate selection within the follicle. In cerebellar development, it serves as a receptor for neuronal DNER, impacting the differentiation of Bergmann glia. NOTCH1 also plays roles in repressing neuronal and myogenic differentiation, postimplantation development, mesoderm development, somite formation, and neurogenesis. Additionally, it modulates the balance between motile and immotile cilia for left/right symmetry determination. The protein interacts with various partners, including DNER, DTX1, DTX2, RBPJ/RBPSUH, MAML1, MAML2, MAML3, SNW1, AAK1, FBXW7, SGK1, HIF1AN, SNAI1, MDM2A, BCL6, THBS4, CCN3, DLL4, ZMIZ1, MEGF10, DLL1, JAG1, PRAG1, PSEN1, and ZFP64, highlighting its involvement in intricate signaling networks and regulatory processes.