PDCD6IP Protein, Human (His, Strep)
PDCD6IP Protein, Human (His, Strep) is the recombinant human-derived PDCD6IP, expressed by E. coli , with Strep, His labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
PDCD6IP Protein, Human (His, Strep) is the recombinant human-derived PDCD6IP, expressed by E. coli , with Strep, His labeled tag. ,
ALIX is a multifunctional protein involved in endocytosis, multivesicular body (MVB) biogenesis, membrane repair, cytokinesis, apoptosis, and tight junction maintenance. As a Class E VPS protein, it facilitates cargo sorting into intralumenal vesicles (ILVs) within MVBs by interacting with ESCRT complexes (ESCRT-O, -I, -II, -III) and binding lysobisphosphatidic acid (LBPA). It acts as an adapter for ESCRT-III proteins (e.g., CHMP4) and is essential for cytokinesis completion. ALIX regulates exosome biogenesis with SDC1/4 and SDCBP and may modulate apoptosis and cell proliferation. By interacting with F-actin, PARD3, and TJP1, it ensures proper actomyosin-tight junction assembly in epithelial polarity (By similarity). Additionally, ALIX supports HIV-1 budding by functionally replacing TSG101 via CHMP4B interaction, highlighting its role in viral release and topologically similar membrane fission events.
Technical Parameters
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Species Human
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Source E. coli
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Tag Strep;His
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Accession
Q8WUM4-1 (M1-R698)
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Gene ID10015
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Protein Length
Partial
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Synonyms
PDCD6IP; Dopamine Receptor Interacting Protein 4; Programmed Cell Death 6 Interacting Protein; ALG-2 Interacting Protein X; Programmed Cell Death 6-Interacting Protein; ALG-2 Interacting Protein 1; AIP1; ALG-2-Interacting Protein 1; Hp95; KIAA1375; Alix;
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AA Sequence
MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFAR
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Predicted Molecular Mass
81 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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