Stabilin-2 Protein, Human (His)

Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

Stabilin-2 Protein serves as a multifunctional phosphatidylserine receptor, facilitating the engulfment of apoptotic cells, and functions as a hyaluronan receptor, mediating the endocytosis of hyaluronic acid (HA). Additionally, it acts as a primary systemic scavenger receptor, binding to various ligands such as heparin, chondroitin sulfate, dermatan sulfate, non-glycosaminoglycan molecules, acetylated low-density lipoprotein, pro-collagen propeptides, and advanced glycation end products. Stabilin-2 may play a crucial role in maintaining tissue integrity through support for extracellular matrix turnover and contribute to the fluidity of bodily liquids by resorbing hyaluronan. This receptor also functions as a counter receptor, facilitating lymphocyte recruitment in the hepatic vasculature, and displays the ability to bind Gram-positive and Gram-negative bacteria, potentially playing a role in defense against bacterial infection. The proteolytically processed 190 kDa form of Stabilin-2 serves as an endocytosis receptor for heparin internalization, hyaluronan, and chondroitin sulfate. Interactions with GULP1, heparin, alpha-M/beta-2 integrin, and thymosin beta 4 further underscore the diverse functions of Stabilin-2.

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED₅₀ for this effect is 0.09732 nM.

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  Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED₅₀ for this effect is 0.09732 nM.

Human

E. coli

C-6*His

Q8WWQ8 (G2198-V2295)

55576  [NCBI]

Partial

GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDV

Approximately 12 kDa, based on SDS-PAGE under reducing conditions.

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  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.