2. Gene
  3. STAB2 - stabilin 2 Gene

STAB2 - stabilin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FEX2; HARE; FEEL2; FELL2; FELE-2; SCARH1

Gene ID: 55576 | Gene type: protein coding

About STAB2

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,587,273-103,766,719 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 2 paralogues. Biased expression in spleen (RPKM 18.3), liver (RPKM 4.3) and 2 other tissues.

Summary

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]

STAB2 Products(1)

mRNA Protein Name
NM_017564.10 NP_060034.9 stabilin-2 precursor

STAB2 Protein Structure

EGF_3

EGF_3: EGF domain (245 - 275)

Fasciclin

Fasciclin: Fasciclin domain (383 - 505)

Fasciclin

Fasciclin: Fasciclin domain (527 - 654)

EGF_3

EGF_3: EGF domain (957 - 993)

Fasciclin

Fasciclin: Fasciclin domain (1008 - 1129)

Fasciclin

Fasciclin: Fasciclin domain (1149 - 1265)

EGF_3

EGF_3: EGF domain (1475 - 1511)

EGF_3

EGF_3: EGF domain (1517 - 1553)

EGF_3

EGF_3: EGF domain (1559 - 1595)

Fasciclin

Fasciclin: Fasciclin domain (1618 - 1726)

Fasciclin

Fasciclin: Fasciclin domain (1754 - 1882)

EGF_3

EGF_3: EGF domain (2086 - 2121)

EGF_3

EGF_3: EGF domain (2132 - 2164)

Xlink

Xlink: Extracellular link domain (2198 - 2290)

Fasciclin

Fasciclin: Fasciclin domain (2355 - 2446)

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  • 2551 a.a.
Protein Preferred Names Protein Names

stabilin-2

CD44-like precursor FELL

Recombinant STAB2 Proteins

Cat. No. Product Name Accession Purity
HY-P79068 Stabilin-2 Protein, Human (CHO, His) Q8WWQ8 (S20-T2458) ≥95%
HY-P79135 Stabilin-2 Protein, Human (His) Q8WWQ8 (G2198-V2295) ≥95%

Related Diseases

Diseases Alias
Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome

CFZS

Congenital Nonprogressive Myopathy With Moebius And Robin Sequences

Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence

Cfz Syndrome

Carey Fineman Ziter Syndrome

Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences

Myopathy-Moebius-Robin Syndrome

CFZS1

Moebius Sequence, Robin Complex, And Hypotonia

Congenital Non-Progressive Myopathy With Moebius And Robin Sequences
Factor Viii Deficiency

Autosomal Hemophilia A

Hemophilia A

Autosomal Factor Viii Deficiency

Classic Hemophilia A

Congenital Factor Viii Disorder

Subhemophilia

Factor 8 Deficiency, Congenital

Factor Viii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13862 STAB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta STAB2 VGNC VGNC:77957
Felis catus STAB2 VGNC VGNC:65740
Rattus norvegicus STAB2 RGD RGD:628822
Bos taurus STAB2 VGNC VGNC:35349
Canis familiaris STAB2 VGNC VGNC:46869
Mus musculus STAB2 MGD MGI:2178743