TEAD1 Protien, Human (HEK293, His)
TEAD1 protein is a key transcription factor that plays a crucial role in the Hippo signaling pathway, regulating proliferation and apoptosis to control organ size and suppress tumors. TEAD1 mediates a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1, leading to inactivation of YAP1 and WWTR1/TAZ. TEAD1, Human (HEK293, His) is the recombinant human-derived TEAD1 protein, expressed by HEK293, with C-His;C-Avi labeled tag.
- Species: Human
- Source: HEK293
-
Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Help & FAQs
Biological Activity
TEAD1 protein is a key transcription factor that plays a crucial role in the Hippo signaling pathway, regulating proliferation and apoptosis to control organ size and suppress tumors. TEAD1 mediates a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1, leading to inactivation of YAP1 and WWTR1/TAZ. TEAD1, Human (HEK293, His) is the recombinant human-derived TEAD1 protein, expressed by HEK293, with C-His;C-Avi labeled tag.
TEAD1, a pivotal transcription factor, assumes a crucial role in the Hippo signaling pathway, a pathway integral to organ size control and tumor suppression by regulating proliferation and apoptosis. Within this pathway, TEAD1 participates in a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1, leading to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. By mediating the gene expression of YAP1 and WWTR1/TAZ, TEAD1 governs cellular processes such as proliferation, migration, and epithelial-mesenchymal transition (EMT). Notably, it binds specifically and cooperatively to the SPH and GT-IIC 'enhansons,' activating transcription in a cell-specific manner, with the activation function potentially mediated by a cell-specific transcriptional intermediary factor (TIF). TEAD1 is also implicated in cardiac development and interacts with YAP1 and WWTR1/TAZ, emphasizing its intricate involvement in regulatory networks.
Technical Parameters
-
Species Human
-
Source HEK293
-
Tag C-10*His
-
Accession
P28347-1 (S210-D426)
-
Gene ID7003
-
Molecular Construction
-
N-term
-
TEAD1 (S210-D426)
Accession # P28347-1 -
10*His
-
C-term
-
-
Protein Length
Partial
-
Synonyms
TEAD1; Protein GT-IIC; Prev. TCF13; TCF-13; Prev. AA; TEAD-1; Transcriptional Enhancer Factor TEF-1; Atrophia Areata, Peripapillary Chorioretinal Degeneration; TEF-1; TEA Domain Family Member 1; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Fa
-
AA Sequence
SIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
