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TLR2 Protein, Rat (sf9, His)

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TLR2 Protein cooperates with LY96 to initiate innate immune response against bacterial lipoproteins and microbial cell wall components. It also cooperates with TLR1 or TLR6 for the immune response to bacterial lipoproteins or lipopeptides. This involves NF-kappa-B activation, cytokine secretion, and induction of inflammatory response via MYD88 and TRAF6 signaling pathways. TLR2 Protein, Rat (sf9, His) is the recombinant rat-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Rat
  • Source: Sf9 insect cells
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

TLR2 Protein cooperates with LY96 to initiate innate immune response against bacterial lipoproteins and microbial cell wall components. It also cooperates with TLR1 or TLR6 for the immune response to bacterial lipoproteins or lipopeptides. This involves NF-kappa-B activation, cytokine secretion, and induction of inflammatory response via MYD88 and TRAF6 signaling pathways. TLR2 Protein, Rat (sf9, His) is the recombinant rat-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Background

The TLR2 protein functions in cooperation with LY96 to initiate the innate immune response against bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 or TLR6 for the innate immune response to bacterial lipoproteins or lipopeptides. This process involves the activation of NF-kappa-B, cytokine secretion, and the induction of the inflammatory response through signaling pathways involving MYD88 and TRAF6.

Technical Parameters

  • Species Rat
  • Source Sf9 insect cells
  • Tag C-His
  • Accession

    Q6YGU2 (L17-Q587)

  • Gene ID
    310553  [NCBI]
  • Molecular Construction
    • N-term
    • TLR2 (L17-Q587)
      Accession # Q6YGU2
    • His
    • C-term
  • Protein Length

    Partial

  • Synonyms

    TLR2; CD282; Toll Like Receptor 2; Toll/Interleukin-1 Receptor-Like Protein 4; Toll-Like Receptor 2; Toll-Like Receptor; TIL4; CD282 Antigen

  • AA Sequence

    LSREGHSAQASLSCDAAGVCDGSSRSFTSIPSGLTANTKKLDLSFNKITYIGHGDLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNPYRTLGETSLFSNLTNLQTLRVGNVDTFSEIRRIDFAGLTSLNELEIQVLSLGNYESRSLQSIRDIYHLTLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKLLRYILELMEVEFDHCTLNGVGNFNPSESDVVRELGKVETVTIRSLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACEGGWPSLQSLVLSQNHLRSIRKTAEILLTLKNLTALDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPEASLFPVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHFICSCELLSFILERPALVHVLVDWPDSYLCDSPPRLHGQRLQDARPSVLECHQ

  • Predicted Molecular Mass

    67.5 kDa

  • Molecular Weight

    Approximately 60 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Formulation

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
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Biological Activity (ED50) Biological Activity (ED50)
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MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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