1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. T Cell CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors
  4. CD282/TLR2 Toll-like Receptor
  5. Toll Like Receptor 2
  6. TLR2 Protein, Rat (sf9, His)

TLR2 Protein, Rat (sf9, His)

Cat. No.: HY-P73589
Handling Instructions

TLR2 Protein cooperates with LY96 to initiate innate immune response against bacterial lipoproteins and microbial cell wall components. It also cooperates with TLR1 or TLR6 for the immune response to bacterial lipoproteins or lipopeptides. This involves NF-kappa-B activation, cytokine secretion, and induction of inflammatory response via MYD88 and TRAF6 signaling pathways. TLR2 Protein, Rat (sf9, His) is the recombinant rat-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR2 Protein, Rat (sf9, His) is 587 a.a., with molecular weight of ~60 kDa.

For research use only. We do not sell to patients.

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Description

TLR2 Protein cooperates with LY96 to initiate innate immune response against bacterial lipoproteins and microbial cell wall components. It also cooperates with TLR1 or TLR6 for the immune response to bacterial lipoproteins or lipopeptides. This involves NF-kappa-B activation, cytokine secretion, and induction of inflammatory response via MYD88 and TRAF6 signaling pathways. TLR2 Protein, Rat (sf9, His) is the recombinant rat-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR2 Protein, Rat (sf9, His) is 587 a.a., with molecular weight of ~60 kDa.

Background

The TLR2 protein functions in cooperation with LY96 to initiate the innate immune response against bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 or TLR6 for the innate immune response to bacterial lipoproteins or lipopeptides. This process involves the activation of NF-kappa-B, cytokine secretion, and the induction of the inflammatory response through signaling pathways involving MYD88 and TRAF6.

Species

Rat

Source

Sf9 insect cells

Tag

C-His

Accession

Q6YGU2 (M1-Q587)

Gene ID
Molecular Construction
N-term
TLR2 (M1-Q587)
Accession # Q6YGU2
His
C-term
Synonyms
CD282; TIL4; TLR2; Toll-like receptor 2
Molecular Weight

Approximately 60 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
TLR2 Protein, Rat (sf9, His)
Cat. No.:
HY-P73589
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