Tlr2 - toll-like receptor 2 Gene

Rattus norvegicus

Gene ID: 310553 | Gene type: protein coding

About Tlr2

Primary_assembly 2: 169,197,419-169,206,630 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 248 orthologues, 26 paralogues and is associated with 138 phenotypes. Biased expression in Thymus (RPKM 134.2), Spleen (RPKM 14.9) and 9 other tissues.

Summary

Enables Lipopeptide binding activity. Involved in several processes, including neurogenesis; positive regulation of interleukin-10 production; and response to molecule of Bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of acute necrotizing pancreatitis; kidney failure; lung disease; pancreatitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (Toll Like Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tlr2 Products(1)

mRNA	Protein	Name
NM_198769.2	NP_942064.1	toll-like receptor 2 precursor

Tlr2 Protein Structure

LRR_1

LRR_8

LRR_1

LRR_RI

PRK15370

LRR_RI

LRRCT

TIR

0
200
400
600
831 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 2

Recombinant Tlr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73589	TLR2 Protein, Rat (sf9, His)	Q6YGU2 (M1-Q587)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100461	C29	Inhibitor	≥98.0%	Unkown
HY-P1180A	Pam3CSK4 TFA	Agonist	99.66%	Unkown
HY-123942	Diprovocim	Agonist	98.35%	Unkown
HY-108471	CU-CPT22	Inhibitor	≥99.0%	Unkown
HY-112146	MMG-11	Antagonist	99.11%	Unkown
HY-110353	CU-T12-9	Agonist	98.94%	Unkown
HY-116213	Sparstolonin B	Antagonist	99.54%	Unkown
HY-N1346	Robinin	Inhibitor	98.77%	Unkown
HY-P2036A	FSL-1 TFA	Agonist	99.76%	Unkown
HY-112146A	MMG-11 quarterhydrate	Antagonist	99.09%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-150501	Diprovocim-X	Agonist	98.64%	Unkown
HY-P1180	Pam3CSK4	Agonist	/	Unkown
HY-P1405	Pam3CSK4-Biotin	Agonist	/	Unkown
HY-P2036	FSL-1	Agonist	/	Unkown
HY-158058	WYJ-2	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr2	NCBI	NCBI:7097
Mus musculus	Tlr2	NCBI	NCBI:24088

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