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Cat. No.: HY-184285

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TLR2 antagonist-2

TLR2 antagonist-2 is a selective TLR2 antagonist with an IC₅₀ of 0.94 μM. TLR2 antagonist-2 inhibits TLR1/2 and TLR2/6 heterodimers. TLR2 antagonist-2 is applicable to the research of inflammatory diseases.

For research use only. We do not sell to patients.

Formula: C₂₃H₁₃F₃N₂O₃
Molecular Weight:422.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TLR2 antagonist-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

TLR2

0.94 μM (IC₅₀)

All Toll-like Receptor (TLR) Isoforms :

In Vitro

TLR2 antagonist-2 (Compound b1) potently inhibits the Pam3CSK4-induced TLR2 signaling pathway in HEK-Blue hTLR2 cells, with an IC₅₀ value of 0.94 μM^[1].
TLR2 antagonist-2 (increasing concentrations; 24 h) selectively inhibits the signaling pathways of TLR1/2 and TLR2/6 heterodimers in THP1-Dual reporter cells, and shows no activity against TLR4 or TLR7/8 signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 422.36
Formula C₂₃H₁₃F₃N₂O₃
SMILES

O=C(C1=CC(C2=CC(C=O)=C(O)C(F)=C2)=NC3=CC=CC=C13)NC4=CC=C(F)C=C4F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jin H, et al. Design, synthesis, and evaluation of 3-fluoro-2-hydroxybenzaldehyde derivatives as TLR2 small molecule antagonists. Bioorganic chemistry. 2026 Jun 08;180:110062. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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