TSSK4 Protein, Human (sf9, GST)
The TSSK4 protein is a critical serine/threonine kinase that is essential for male germ cell development and contributes to mature sperm function. It may participate in the Cre/Creb signaling pathway, phosphorylate CREB1 on "Ser-133" and stimulate this pathway. TSSK4 Protein, Human (sf9, GST) is the recombinant human-derived TSSK4 protein, expressed by sf9 insect cells , with GST tagged.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The TSSK4 protein is a critical serine/threonine kinase that is essential for male germ cell development and contributes to mature sperm function. It may participate in the Cre/Creb signaling pathway, phosphorylate CREB1 on "Ser-133" and stimulate this pathway. TSSK4 Protein, Human (sf9, GST) is the recombinant human-derived TSSK4 protein, expressed by sf9 insect cells , with GST tagged.
TSSK4, a serine/threonine kinase, plays a pivotal role in male germ cell development and contributes to mature sperm function. It is potentially involved in the Cre/Creb signaling pathway, as suggested by its ability to phosphorylate CREB1 on 'Ser-133' in vitro and stimulate the Cre/Creb pathway in cells. Additionally, TSSK4 exhibits phosphorylation activity on CREM at 'Ser-116' in vitro. Another target of TSSK4 phosphorylation is ODF2, with 'Ser-95' being a specific phosphorylation site. These findings underscore the multifaceted involvement of TSSK4 in critical cellular processes related to male germ cell development and sperm functionality.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag GST
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Accession
Q6SA08 (G2-T328)
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Gene ID283629
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Protein Length
Partial
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Synonyms
TSSK4; C14orf20; STK22E; TSSK5; Testis-specific serine/threonine-protein kinase 4; TSK-4; TSSK-4; Testis-specific kinase 4; EC 2.7.11.1; Serine/threonine-protein kinase 22E; Serine/Threonine Kinase 22E; Chromosome 14 Open Reading Frame 20; Non-Specific Se
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AA Sequence
GKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQPTHEIRLLEAMCQLHNTTKQHQSLQITT
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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