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Resiniferatoxin

(Synonyms: (+)-Resiniferatoxin)
11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period.

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  • Purity: 99.77%
  • CAS No.: 57444-62-9
  • Formula: C37H40O9
  • Molecular Weight:628.71
  • Storage:

    -20°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Resiniferatoxin Chemical Structure
    Resiniferatoxin Chemical Structure
  • Experimental Validation Results for Resiniferatoxin
  • Experimental Validation Results for Resiniferatoxin
  • Experimental Validation Results for Resiniferatoxin
  • Experimental Validation Results for Resiniferatoxin
  • Experimental Validation Results for Resiniferatoxin
CAS No.: 57444-62-9
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In Vivo Efficacy StudyIHCWBRT-PCR
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  • Resiniferatoxin Chemical Structure
    Resiniferatoxin Chemical Structure
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  • 1/16

    Resiniferatoxin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 23:e07128. [Abstract]

    Customer Validation
     Representative images of IHC staining of uteri from mice with PGP9.5. Scale bar, 50 μm. Red arrows: positive PGP9.5 staining. Twenty‐four female mice were randomly assigned to four groups (n = 6 per group): 1) Control (vehicle + vehicle), 2) RTX‐C (vehicle + RTX), 3) M (tamoxifen + vehicle), and 4) RTX‐M (tamoxifen + RTX). Sensory denervation was induced by intraperitoneal injection of RTX (Resiniferatoxin) at 150 µg/kg every 5 days, beginning on day 42. All mice were euthanized on day 63.

  • 1/16

    Resiniferatoxin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 23:e07128. [Abstract]

    Customer Validation
     RH&E, Masson trichrome staining of mice uteri at Day 63 and the corresponding horizon of multiple IF staining of E‐CAD (green), αSMA (red), and nucleus (DAPI, Blue). The yellow dotted circle showed the location of the ectopic lesion. The black dotted frame was the zoomed‐out version of the middle picture. Twenty‐four female mice were randomly assigned to four groups (n = 6 per group): 1) Control (vehicle + vehicle), 2) RTX‐C (vehicle + RTX), 3) M (tamoxifen + vehicle), and 4) RTX‐M (tamoxifen + RTX). Sensory denervation was induced by intraperitoneal injection of RTX (Resiniferatoxin) at 150 µg/kg every 5 days, beginning on day 42. All mice were euthanized on day 63.

  • 1/16

    Resiniferatoxin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 23:e07128. [Abstract]

    Customer Validation
     Twenty‐four female mice were randomly assigned to four groups (n = 6 per group): 1) Control (vehicle + vehicle), 2) RTX‐C (vehicle + RTX), 3) M (tamoxifen + vehicle), and 4) RTX‐M (tamoxifen + RTX). Sensory denervation was induced by intraperitoneal injection of RTX (Resiniferatoxin) at 150 µg/kg every 5 days, beginning on day 42. All mice were euthanized on day 63.

  • 1/16

    Resiniferatoxin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 23:e07128. [Abstract]

    Customer Validation
     Relative expression levels of Fn, Col1a1, Acta2 (gene name of αSMA) in Control, RTX-C, M and RTX-M groups detected by qPCR. Twenty‐four female mice were randomly assigned to four groups (n = 6 per group): 1) Control (vehicle + vehicle), 2) RTX‐C (vehicle + RTX), 3) M (tamoxifen + vehicle), and 4) RTX‐M (tamoxifen + RTX). Sensory denervation was induced by intraperitoneal injection of RTX (Resiniferatoxin) at 150 µg/kg every 5 days, beginning on day 42. All mice were euthanized on day 63.

  • 1/16

    Resiniferatoxin purchased from MedChemExpress. Usage Cited in: iScience. 2025 Jan 17;28(2):111831. [Abstract]

    Customer Validation
     RTX was dissolved in 2% DMSO with 0.15% Tween 80 in PBS. 4-week-old C57BL/6J male mice were injected s.c. in the flank on consecutive days with three increasing doses of RTX (Resiniferatoxin, 30, 70, and 100 μg/kg). Control mice were treated with vehicle alone. Mice were rested for 4 weeks before experiments.

  • Resiniferatoxin