Risperidone hydrochloride (Synonyms: R 64 766 hydrochloride)

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Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

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CAS No. : 666179-74-4

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Other In-stock Forms of Risperidone hydrochloride:

Risperidone

Other Forms of Risperidone hydrochloride:

Risperidone In-stock
Risperidone mesylate Get quote

6 Publications Citing Use of MCE Risperidone hydrochloride

In Vivo Efficacy Study

Bio/Physico-chemical Assay

RT-PCR

: Risperidone hydrochloride purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2024 Oct:168:107138. [Abstract]; Risperidone (0.3 mg/kg, i.p.). Expression of OT signaling related genes in the hippocampus. RT-PCR (n=8–10) analysis were performed on brain tissues from the hippocampus of each group. The mRNA level of CD38, OTR and OT in the hippocampus are presented.

: Risperidone hydrochloride purchased from MedChemExpress. Usage Cited in: Psychoneuroendocrinology. 2024 Oct:168:107138. [Abstract]; Expression of OT signaling related genes in the hippocampus. Western blot (n=6–8) analysis were performed on brain tissues from the hippocampus of each group. Western blot images and quantification of the band intensity compared to the basal level.

: Risperidone hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2023 Apr 21:14:1161964. [Abstract]; Risperidone (0.1 mg/kg, p.o.; 0.1 ml/g) or aripiprazole also reduced MK801-induced schizophrenia-like behavior, 50B had a lower impact on reducing the distance mice traveled compared with risperidone, but had similar effects compared with aripiprazole.

: Risperidone hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2023 Apr 21:14:1161964. [Abstract]; Risperidone (1 or 5 mg/kg, p.o.; 0.1 ml/10 g). 50A and 50B did not induce catalepsy in male mouse bar test. Results are expressed as mean ± SD (n = 5–6).

: Risperidone hydrochloride purchased from MedChemExpress. Usage Cited in: Eur J Pharm Sci. 2023 Aug 1:187:106475. [Abstract]; Reversible inhibition of CYP2J2 metabolism of arachidonic acid (AA) to 14,15-epoxyeicosatrienoic acid (14,15-EET) by Risperidone (0-20 μM).

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

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Description

IC₅₀ & Target

5-HT₂ Receptor

4.8 nM (Ki)

D₂ Receptor

5.9 nM (Ki)

5-HT_2A Receptor

P-Glycoprotein

In Vitro

Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.95

Formula

C₂₃H₂₈ClFN₄O₂

CAS No.

666179-74-4

SMILES

O=C1C(CCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)=C(C)N=C5N1CCCC5.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72. [Content Brief]

[2]. Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12(1):197-204. [Content Brief]

[3]. Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21(3):259-67. [Content Brief]

[4]. Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64. [Content Brief]

Animal Administration
^[4]

Rats^[4]
A total of 211 Long-Evans rats (56 females and 155 males) are used. Within each study, three groups of roughly equal numbers of rats receive injections of 1.0 mg/kg of Risperidone, 3.0 mg/kg of Risperidone, or the vehicle used for the Risperidone solution as a control. In the first experiment, twenty-six male rats (n=9 in the vehicle and 3.0 mg/kg Risperidone groups; n=8 in the 1.0 mg/kg Risperidone group) are tested for locomotor activity for 20 minutes a day beginning at postnatal day 49 and continuing daily until postnatal day 53. A second experiment determined if the locomotor effects of early-life Risperidone treatment persisted well into adulthood. A third experiment ascertains the effects of sex on the locomotor effects of early-life Risperidone seen in young adult rats. In this experiment, sixty male (n=20 per treatment group) and 56 female (n=19 rats in the vehicle and 3.0 mg/kg dose group, n=18 in the 1.0 mg/kg dose group) rats are treated. A fourth experiment assessed reversal learning during adulthood in rats administered earlylife risperidone. Forty-two male rats (n=14 per treatment group) are treated^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72. [Content Brief]

[2]. Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12(1):197-204. [Content Brief]

[3]. Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21(3):259-67. [Content Brief]

[4]. Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64. [Content Brief]

Risperidone hydrochloride Related Classifications

Neurological Disease

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Keywords:

Risperidone666179-74-4R 64 7665-HT ReceptorDopamine ReceptorP-glycoproteinSerotonin Receptor5-hydroxytryptamine ReceptorP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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Risperidone hydrochloride (Synonyms: R 64 766 hydrochloride)

Other Forms of Risperidone hydrochloride:

Risperidone hydrochloride Related Antibodies

6 Publications Citing Use of MCE Risperidone hydrochloride

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

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Biological Activity

Protocol

Purity & Documentation

References

Customer Review

Risperidone hydrochloride Related Antibodies

Risperidone hydrochloride Related Classifications

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Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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