RSV L-protein-IN-3
RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434).
For research use only. We do not sell to patients.
- CAS No.: 868860-35-9
- Formula: C31H34N4O4
- Molecular Weight:526.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 10.4 μM (RSV)[1]
RSV L-protein-IN-3 (compound B) has certain cytotoxicity in HEp-2 cells, the CC50 value is 16 μM[1].
RSV L-protein-IN-3 inhibits transcription of RSV in infected HEp-2 cell with an EC50 value of 2.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEp-2 cell [1]
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Concentration:Infected with RSV Long at a multiplicity of infection(MOI) of 0.1 and incubated for 48 h in the presence or absence of serial dilutions of RSV L-protein-IN-3
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Incubation Time:48 h
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Result:Inhibited transcription of the virus.
Chemical Information
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CAS No. 868860-35-9
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Molecular Weight 526.63
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Formula C31H34N4O4
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SMILES
O=C1C2=C3NC(C4=CC=CC=C4)=NC3=CC=C2C(C)(C)C(N1CCCNCCC5=CC=C(C(OC)=C5)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Michel Liuzzi, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005, 79(20). [Content Brief]
[3]. Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RSV L-protein-IN-3 Related Classifications
HY-154966 Related Classifications
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