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Cat. No.: HY-174334

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RXFP1 receptor agonist-9

RXFP1 receptor agonist-9 is a potent RXFP1 agonist with an EC₅₀ of 2.5 μM and Y_max of 65%. RXFP1 receptor agonist-9 exhibits good microsomal stability, reasonable PK and pharmacological activity. RXFP1 receptor agonist-9 can be used to the study of heart failure.

For research use only. We do not sell to patients.

CAS No.: 2924765-23-9
Formula: C₃₇H₃₄F₅N₃O₇
Molecular Weight:727.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RXFP1 receptor agonist-9 Chemical Structure

CAS No.: 2924765-23-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Parmacokinetics

Species	Dose	Route	T_1/2	AUC	V_ss	CL	F
Rat^[1]	1 mg/kg	i.v.	4.43 h	9.6 μM·h	0.09 L/kg	2.5 mL/min/kg	/
Rat^[1]	10 mg/kg	p.o.	/	/	/	/	6 %

In Vivo

RXFP1 receptor agonist-9 (Compound 39) (0.5-5 mg/min/kg, i.v., daily for 21 days) induces a dose-dependent heart rate increase (consistent with the hemodynamic profile of relaxin) in isoflurane-anesthetized naïve rats^[1].
RXFP1 receptor agonist-9 (25 mg/kg, i.v., respectively on day 6 and 7) elicites significant interpubic ligament (IPL) expansion, which recapitulated the effect of relaxin in C57BL/6 mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Isoflurane-anesthetized male Sprague Dawley (SD) rat model
Dosage:

5 mg/min/kg
Administration:

IV, 60 min
Result:

Induced a 25% increase on heart rate.

Animal Model:

Isoflurane-anesthetized male Sprague Dawley (SD) rat model
Dosage:

0.5 mg/min/kg, 1.5 mg/min/kg, 5 mg/min/kg,
Administration:

Intravenous injection (i.v.), 60 min
Result:

Observed a dose-dependent increase at 1.5 and 5 mg/min/kg while no major effect was observed at 0.5 mg/min/kg.

Animal Model:

Baseline microCT scan acquired for the estrogen primed C57BL/6 female mice pubis (primed with estrogen on day 0)
Dosage:

25 mg/kg,
Administration:

IV, respectively on day 6 and 7
Result:

Showed 500% symphysis widening, and thus IPL expansion.

Chemical Information

CAS No. 2924765-23-9
Molecular Weight 727.67
Formula C₃₇H₃₄F₅N₃O₇
SMILES

O=C(N[C@@H]1[C@@H]2CC[C@H]([C@@H]1C(NC3=CC(C(F)(F)F)=C(C=C3)F)=O)/C2=C/C4CC4)C5=CC(C6=C(C=CC(C(C(O)=O)OC(NC)=O)=C6)F)=CC=C5OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Su S et, al. The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists. J Med Chem. 2025 Jun 12;68(11):12185-12203. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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