SARS-CoV-2-IN-39
Based on 1 Customer Validation
SARS-CoV-2-IN-39 (compound 21) is a SARS-CoV-2 inhibitor with an EC50 of 1 μM. SARS-CoV-2-IN-39 against SARS-CoV-2 by inhibiting of SKP2 protein and stabilizing BECN1.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 2882823-03-0
- Formula: C14H8ClF4NO3
- Molecular Weight:349.66
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
4.73 μM
Compound: 21
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by CCK-8 assay
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[PMID: 37058956] |
| Vero C1008 | EC50 |
1 μM
Compound: 21
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral replication incubated for 24 hrs by IFA assay
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral replication incubated for 24 hrs by IFA assay
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[PMID: 37058956] |
Chemical Information
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CAS No. 2882823-03-0
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Appearance Solid
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Molecular Weight 349.66
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Formula C14H8ClF4NO3
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Color White to off-white
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SMILES
O=C(C1=C(C=C(C(Cl)=C1)F)O)NC2=CC=C(C=C2)OC(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (143.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8599 mL | 14.2996 mL | 28.5992 mL | 71.4980 mL |
| 5 mM | 0.5720 mL | 2.8599 mL | 5.7198 mL | 14.2996 mL | |
| 10 mM | 0.2860 mL | 1.4300 mL | 2.8599 mL | 7.1498 mL | |
| 15 mM | 0.1907 mL | 0.9533 mL | 1.9066 mL | 4.7665 mL | |
| 20 mM | 0.1430 mL | 0.7150 mL | 1.4300 mL | 3.5749 mL | |
| 25 mM | 0.1144 mL | 0.5720 mL | 1.1440 mL | 2.8599 mL | |
| 30 mM | 0.0953 mL | 0.4767 mL | 0.9533 mL | 2.3833 mL | |
| 40 mM | 0.0715 mL | 0.3575 mL | 0.7150 mL | 1.7875 mL | |
| 50 mM | 0.0572 mL | 0.2860 mL | 0.5720 mL | 1.4300 mL | |
| 60 mM | 0.0477 mL | 0.2383 mL | 0.4767 mL | 1.1916 mL | |
| 80 mM | 0.0357 mL | 0.1787 mL | 0.3575 mL | 0.8937 mL | |
| 100 mM | 0.0286 mL | 0.1430 mL | 0.2860 mL | 0.7150 mL |
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