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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
node
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "node" in MCE Product Catalog:
Cat. No.: HY-K0357
MCE Mouse Mature B Cell Negative Selection Kit enables the efficient isolation of mature B cells from single-cell suspensions prepared from mouse spleen, lymph nodes, or bone marrow. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells (non-B cells), followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of mouse mature B cells.
Cat. No.: HY-P3269A
Target:
Research Areas:
Cat. No.: HY-L252
75 compounds
Carbohydrate metabolism serves as a central hub for energy supply and biosynthesis in living organisms and plays a critical role in the onset and progression of various diseases. In recent years, studies have shown that tumor cells reprogram their energy metabolism through aerobic glycolysis (the Warburg effect) to support rapid proliferation. Immune cells also rely on specific carbohydrate metabolic pathways to regulate their activation and differentiation states, while disorders such as diabetes and metabolic syndrome arise directly from dysregulation of carbohydrate metabolism. In addition, enzymes and key metabolic nodes involved in carbohydrate metabolism have become important targets for drug discovery, and therapeutic strategies targeting glycolysis, the pentose phosphate pathway, and energy metabolism are continuously advancing the treatment of cancer and metabolic diseases. Therefore, systematic analysis of carbohydrate metabolic networks and their associated metabolites is of great significance for elucidating disease mechanisms and developing novel therapeutic approaches.
The MCE Carbohydrate Metabolism Metabolite Library is constructed based on classical carbohydrate metabolic pathways and contains 75 metabolites. It systematically integrates key metabolic networks, including glycolysis, the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle, monosaccharide metabolism, and sugar acid interconversions. The library comprehensively covers core metabolic nodes from glucose uptake and utilization to energy production and biosynthesis, while also incorporating important upstream and downstream intermediates. It enables accurate representation of intracellular metabolic flux dynamics and is well suited for applications such as metabolic flux analysis, target validation, and mechanistic studies. Furthermore, it provides robust support for multi-omics integration and the development of precision intervention strategies.
Cat. No.: HY-P702872
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LASP1; Lasp-1; LIM And SH3 Protein 1; Metastatic Lymph node Gene 50 Protein; MLN50; MLN 50; LIM And SH3 Domain Protein 1; LASP-1
Species:
Human
Source:
E. coli
Cat. No.: HY-P702873
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LASP1; Lasp-1; LIM And SH3 Protein 1; Metastatic Lymph node Gene 50 Protein; MLN50; MLN 50; LIM And SH3 Domain Protein 1; LASP-1
Species:
Mouse
Source:
E. coli
Cat. No.: HY-W014610
CAS No.: 77-83-8
Synonyms: Ethyl methylphenylglycidate
Target:
Cat. No.: HY-159751
Target:
Research Areas:
HS101 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .
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HS103
Cat. No.: HY-159752
Cat. No.: HY-186086
CAS No.: 2953276-07-6
RM-041 is a selective, orally active KRAS G13C (ON) inhibitor that forms a covalent complex with KRAS G13C (ON) and Cyclophilin A. RM-041 blocks the binding of RAS effector proteins via steric hindrance, and then covalently binds to Cys-13 to form an irreversible inhibitory complex, thereby inhibiting the proliferation of KRAS G13C mutant cancer cells. RM-041 induces regression of KRAS G13C tumors in cellular and xenograft tumor models. RM-041 exerts a synergistic effect when combined with upstream node inhibitors (such as SHP2 inhibitors). RM-041 can be used for the research of non-small cell lung cancer .
Cat. No.: HY-P811085
Synonyms: CD62L, Lnhr, Ly-22, Ly22, Sell, L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, Lymphocyte antigen 22, Lymphocyte surface MEL-14 antigen, LAM-1, LECAM1
Cat. No.: HY-P86242
Synonyms: Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340;
Cat. No.: HY-169478
CAS No.: 2924606-55-1
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that can be used to generate supramolecular lipid nanoparticles (SMLNPs) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod (HY-13740) with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies .
Cat. No.: HY-160740
CAS No.: 2762571-32-2
Antitumor agent-148 (Example 1) is an anti-cancer agent. Antitumor agent-148 effectively inhibits the growth, migration and invasion of cancer cells. Antitumor agent-148 significantly inhibits the lymphatic metastasis of breast cancer cells in mouse models. Antitumor agent-148 can be used for the study of malignant tumors such as breast cancer, lung cancer and gastric cancer .
Cat. No.: HY-P86166
Synonyms: Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340;
Cat. No.: HY-P991964
Synonyms: Rendomab-B49
Target:
Research Areas:
Cat. No.: HY-P71269
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A11; MLN70; S100 Calcium Binding Protein A11; S100 Calcium-Binding Protein A11 (Calgizzarin); S100C; Epididymis Secretory Protein Li 43; Calgizzarin; S100 Calcium-Binding Protein A11; Metastatic Lymph node Gene 70 Protein; S100 Calcium-Binding Protein
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P72482
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A11; MLN70; S100 Calcium Binding Protein A11; S100 Calcium-Binding Protein A11 (Calgizzarin); S100C; Epididymis Secretory Protein Li 43; Calgizzarin; S100 Calcium-Binding Protein A11; Metastatic Lymph node Gene 70 Protein; S100 Calcium-Binding Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P78778
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CLEC4G; LSECtin; C-Type Lectin Domain Family 4 Member G; C-Type Lectin Domain Family 4, Member G; LSECTIN; CLEC4G Protein; UNQ431; DTTR431; Liver And Lymph node Sinusoidal Endothelial Cell C-Type Lectin; LP2698; C-Type Lectin Superfamily 4, Member G
Species:
Human
Source:
HEK293
Cat. No.: HY-P80658
Synonyms: ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
