LSECtin/CLEC4G Protein, Human (HEK293, Fc)
Based on 1 Customer Validation
The LSECtin/CLEC4G protein displays unique carbohydrate binding characteristics that favor mannose, N-acetylglucosamine (GlcNAc), and fucose in a Ca(2+)-dependent manner, as shown in vitro. Notably, it serves as a receptor for Japanese encephalitis virus during microbial infection, highlighting its role in viral recognition and host-pathogen interactions. LSECtin/CLEC4G Protein, Human (Fc) is the recombinant human-derived LSECtin/CLEC4G protein, expressed by E. coli , with N-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The LSECtin/CLEC4G protein displays unique carbohydrate binding characteristics that favor mannose, N-acetylglucosamine (GlcNAc), and fucose in a Ca(2+)-dependent manner, as shown in vitro. Notably, it serves as a receptor for Japanese encephalitis virus during microbial infection, highlighting its role in viral recognition and host-pathogen interactions. LSECtin/CLEC4G Protein, Human (Fc) is the recombinant human-derived LSECtin/CLEC4G protein, expressed by E. coli , with N-hFc labeled tag.
Background
The LSECtin/CLEC4G Protein exhibits a distinctive carbohydrate binding profile, showing affinity for mannose, N-acetylglucosamine (GlcNAc), and fucose in a Ca(2+)-dependent manner, as observed in in vitro studies. Notably, LSECtin/CLEC4G acts as a receptor for Japanese encephalitis virus in the context of microbial infection, indicating its functional role in viral recognition and host-pathogen interactions. This specific carbohydrate-binding pattern underscores the molecular versatility of LSECtin/CLEC4G and its potential significance in immune responses to pathogens.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source HEK293
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Tag N-hFc
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Accession
Q6UXB4 (K55-C293)
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Molecular Construction
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N-term
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hFc
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CLEC4G (K55-C293)
Accession # Q6UXB4 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
CLEC4G; LSECtin; C-Type Lectin Domain Family 4 Member G; C-Type Lectin Domain Family 4, Member G; LSECTIN; CLEC4G Protein; UNQ431; DTTR431; Liver And Lymph Node Sinusoidal Endothelial Cell C-Type Lectin; LP2698; C-Type Lectin Superfamily 4, Member G
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AA Sequence
KASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC
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Predicted Molecular Mass
52.9 kDa
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Molecular Weight
Approximately 58-66 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.2 M NaCl, 6% trehalose, pH 7.5.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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