CLEC4G - C-type lectin domain family 4 member G Gene

Also Known as LP2698; UNQ431; DTTR431; LSECtin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339390

About CLEC4G

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,728,957-7,732,110 (from NCBI)

This gene has 5 transcripts (splice variants), 875 orthologues and 14 paralogues. Biased expression in liver (RPKM 17.2), lymph node (RPKM 6.5) and 4 other tissues.

Summary

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type Lectin Receptors are Pattern Recognition Receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile Filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

CLEC4G Products (2)

mRNA Protein Name
NM_001244856.2 NP_001231785.1 C-type lectin domain family 4 member G isoform 2
NM_198492.4 NP_940894.1 C-type lectin domain family 4 member G isoform 1

CLEC4G Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (183 - 289)

  • 0
  • 100
  • 200
  • 293 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member G

  • C-type lectin superfamily 4, member G

CLEC4G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLEC4G Q6UXB4 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CLEC4G Q6UXB4 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 PTPN5 Homo sapiens P54829
Y2H Prey Pooling
32296183
Intra
CLEC4G Q6UXB4 PTPN5 Homo sapiens P54829
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 SIGLEC12 Homo sapiens Q96PQ1
Y2H Prey Pooling
32296183
Intra
CLEC4G Q6UXB4 SIGLEC12 Homo sapiens Q96PQ1
Validated Y2H
32296183
Intra
CLEC4G Q6UXB4 SIGLEC12 Homo sapiens Q96PQ1
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CLEC4G Q6UXB4 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
CLEC4G Q6UXB4 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CLEC4G Q6UXB4 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 IFI35 Homo sapiens P80217
Y2H
18624398
Intra
CLEC4G Q6UXB4 IFI35 Homo sapiens P80217
Anti Tag CoIP
18624398
Intra
CLEC4G Q6UXB4 MTOR Homo sapiens P42345
Anti Tag CoIP
33106485
Intra
CLEC4G Q6UXB4 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
CLEC4G Q6UXB4 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
CLEC4G Q6UXB4 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra
CLEC4G Q6UXB4 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC4G Proteins

Cat. No. Product Name Accession Purity
HY-P78778 LSECtin/CLEC4G Protein, Human (HEK293, Fc) Q6UXB4 (K55-C293) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lymphocytic Choriomeningitis

  • Lcm

  • Lymphocytic Meningitis

  • Lymphocytic Choriomeningitis Virus Encephalomyelitis

  • Lymphocytic Meningoencephalitis

  • Non-Arthropod Borne Lymphocytic Choriomeningitis

  • Lcm - [Lymphocytic Choriomeningitis]

  • Benign Lymphocytic Meningitis

  • Meningitis Due To Lymphocytic Choriomeningitis Virus
Japanese Encephalitis

  • Japanese B Encephalitis

  • Je

  • Encephalitis Japanese

  • Encephalitis, Japanese

  • Russian Autumnal Encephalitis

  • Je - [Japanese Encephalitis]

  • Japanese Encephalitis Virus Disease

  • Jbe - [Japanese B Encephalitis}

  • B Type Encephalitis
Encephalitis

  • Mumps Encephalitis

  • Mumps Meningoencephalitis

  • Herpes Simplex Neuroinvasion

  • Herpetic Encephalitis

  • Herpetic Encephalopathy

  • Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

  • Encephalitis Due To Herpesviridae

  • Encephalitis Due To Herpesvirus

  • Herpes Encephalitis

  • Herpesviral Encephalitis

  • Herpes Simplex Encephalitis

  • Hsv - [Herpes Simplex Virus] Encephalitis

  • Herpes Virus Encephalitis

  • Simian B Disease

  • Simian B Disorder

  • Encephalitis Nec

  • Idiopathic Encephalitis
Argentine Hemorrhagic Fever

  • Argentinian Hemorrhagic Fever

  • Junin Hemorrhagic Fever

  • Hemorrhagic Fever, Argentinian

  • Ahf - [Argentinian Haemorrhagic Fever]

  • Argentine Haemorrhagic Fever

  • Junin Haemorrhagic Fever
Lassa Fever

  • Lf

  • Lassa Hemorrhagic Fever

  • Lf - [Lassa Fever]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02796 CLEC4G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLEC4G VGNC VGNC:27434
Canis familiaris CLEC4G VGNC VGNC:39333
Felis catus CLEC4G VGNC VGNC:60953
Mus musculus CLEC4G MGD MGI:1923113
Rattus norvegicus CLEC4G RGD RGD:1597482
Others CLEC4G NCBI