IFI35 - interferon induced protein 35 Gene

Also Known as IFP35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3430

About IFI35

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,006,784-43,014,456 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 18.2), appendix (RPKM 14.5) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of signal transduction. Located in several cellular components, including cytosol; extracellular space; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

IFI35 Products (2)

mRNA	Protein	Name
NM_001330230.2	NP_001317159.1	interferon-induced 35 kDa protein isoform 2
NM_005533.5	NP_005524.2	interferon-induced 35 kDa protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	10950963	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8954125	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in macrophage activation involved in immune response	IDA IDA: Inferred from direct assay	29038465	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	29350881	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	29350881	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	29038465	GOA
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	29038465	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	29038465	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10950963	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10779520	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	29038465	GOA
located in membrane	IDA IDA: Inferred from direct assay	10950963	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8288566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFI35 Protein Structure

IFP_35_N

NID

0
100
200
286 a.a.

Protein Preferred Names	Protein Names
interferon-induced 35 kDa protein	IFP 35

IFI35 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	IFI35	P80217	CLEC4G	Homo sapiens	Q6UXB4	Confocal	18624398
Intra	IFI35	P80217	CLEC4G	Homo sapiens	Q6UXB4	Anti Tag CoIP	18624398

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Stomatitis
Mouth Disease	Mouth Diseases Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS06555	IFI35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21600	Ifi35 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28118	Ifi35 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFI35	MGD	MGI:1917360
Rattus norvegicus	IFI35	RGD	RGD:1304553
Bos taurus	IFI35	VGNC	VGNC:30044
Canis familiaris	IFI35	VGNC	VGNC:41872
Felis catus	IFI35	VGNC	VGNC:67697
Macaca mulatta	IFI35	VGNC	VGNC:73564
Others	IFI35	NCBI