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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
β-Secretase
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "β-Secretase" in MCE Product Catalog:
13
13 Cited Publications
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LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
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Cat. No.: HY-N0702
CAS No.: 20183-47-5
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Flavonoids Flavones Aconitum apetalum (Huth) B. Fedtsch. Plants Rhamnaceae Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-P1962
CAS No.: 350228-37-4
Synonyms: [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)
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Cat. No.: HY-B0703
CAS No.: 236395-14-5
Synonyms: BIA 2-093
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Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
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β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
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NB-360 is a potent, brain penetrable and orally active β‐secretase 1/2 (BACE1/BACE2) dual inhibitor with IC50 values of 5 and 6 nM. NB-360 can inhibit amyloid-β protein accumulation. NB-360 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease .
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BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a K i value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes .
Cat. No.: HY-N2215
CAS No.: 105317-67-7
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Liliaceae Monophenols Simple Phenylpropanols Aloe vera (L.) Burm. f. Phenols Phenylpropanoids Plants
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Cat. No.: HY-N1280
CAS No.: 129280-33-7
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Flavonoids Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Isoflavones
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Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively .
Cat. No.: HY-N11709
CAS No.: 220114-28-3
Cat. No.: HY-126548
CAS No.: 1818239-19-8
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β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity.
Cat. No.: HY-136736
CAS No.: 263563-09-3
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β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease .
Cat. No.: HY-10104
CAS No.: 913071-81-5
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GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM). GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD) .
Cat. No.: HY-139720
CAS No.: 2760674-85-7
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β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (Ki = 0.13 nM).
Cat. No.: HY-P4428
CAS No.: 141223-71-4
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Cat. No.: HY-P4899
CAS No.: 310427-94-2
Synonyms: RE(EDANS)EVNLDAEFK(DABCYL)R
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
