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Cat. No.: HY-139720

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β-Secretase Inhibitor III

β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (K_i = 0.13 nM).

For research use only. We do not sell to patients.

CAS No.: 2760674-85-7
Formula: C₂₀H₂₀F₂N₄O₃S
Molecular Weight:434.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

β-Secretase Inhibitor III Chemical Structure

CAS No.: 2760674-85-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (K_i = 0.13 nM).

IC₅₀ & Target

BACE1

All Beta-secretase Isoforms :

BACE1
BACE2

Chemical Information

CAS No. 2760674-85-7
Molecular Weight 434.46
Formula C₂₀H₂₀F₂N₄O₃S
SMILES

O=C(C1=CC2=C(OCCO2)C=N1)NC3=CC=C(F)C([C@@]4(C)N=C(N)S[C@H](C)[C@@H]4F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ueno T, et al. Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. J Med Chem. 2021 Oct 14;64(19):14165-14174. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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β-Secretase Inhibitor III

All Beta-secretase Isoforms