913071-81-5
Chemical Structure
GRL-8234
- CAS No.: 913071-81-5
- Formula:C36H42N4O6S
- Molecular Weight:658.81
IUPAC Name: N1-((2S,3R)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2-yl)-5-(N-methylmethylsulfonamido)-N3-((R)-1-phenylethyl)isophthalamide
InChIKey: HIQWWDCRULXYDF-SWROZOJRSA-N
SMILES: O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC(OC)=CC=C3)O)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O
Biological Activity: GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM). GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD)[1].
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GRL-8234 | GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM). GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD). | |||||||||||||||||||||
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Keywords
