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145

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 3β-HSD (1) 5-HT Receptor (3) Acyltransferase (1) ADC Antibody (2) Adenosine Deaminase (1) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (2) Amyloid-β (2) Androgen Receptor (2) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (41) ATM/ATR (1) ATP-binding cassette (ABC) transporters (1) Aurora Kinase (1) Autophagy (5) Bacterial (16) Bcl-2 Family (5) Beta-secretase (1) Biochemical Assay Reagents (5) c-Fms (1) c-Kit (1) c-Met/HGFR (2) C-type Lectin-like Receptors (CTLRs) (1) Calcium Channel (12) Carbonic Anhydrase (1) Caspase (7) Cathepsin (1) CCR (1) CD19 (1) CD276/B7-H3 (1) CD28 (1) CD3 (2) CDK (9) Chloride Channel (1) Cholinesterase (ChE) (2) Complement System (1) COX (2) CTLA-4 (1) CXCR (7) Cytochrome P450 (2) Deubiquitinase (1) Dihydrofolate reductase (DHFR) (1) DNA Methyltransferase (1) DNA/RNA Synthesis (4) Dopamine β-hydroxylase (1) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (7) Endogenous Metabolite (12) Endothelin Receptor (1) Environmental Pollutants (3) Epigenetic Reader Domain (1) Epoxide Hydrolase (1) ERK (16) FAAH (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (5) Ferroptosis (1) FGFR (2) FLAP (1) FLT3 (1) Fluorescent Dye (1) Folate Receptor (FR) (1) Fungal (4) Glucose-6-Phosphate Isomerase (GPI) (2) Glutathione S-transferase (1) GnRH Receptor (3) GPR35 (2) HBV (1) HCN Channel (1) HCV (2) HDAC (4) Hedgehog (2) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) Histone Demethylase (2) Histone Methyltransferase (4) HIV (1) HIV Protease (2) HSP (2) IGF-1R (1) iGluR (1) Influenza Virus (1) Integrin (3) Interleukin Related (10) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (6) JNK (1) Lactate Dehydrogenase (1) Liposome (1) LPL Receptor (1) mAChR (3) MDM-2/p53 (2) MEK (12) mGluR (3) MicroRNA (20) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) Mitosis (1) MMP (1) Mps1 (1) mTOR (1) NADPH Oxidase (1) Necroptosis (1) Neuropeptide Y Receptor (1) NF-κB (14) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (2) Orexin Receptor (OX Receptor) (1) p38 MAPK (8) Parasite (1) PARP (1) PCSK9 (1) PD-1/PD-L1 (1) PDGFR (3) PERK (1) Phosphatase (6) Phosphodiesterase (PDE) (2) Phospholipase (6) PI3K (8) PKA (1) PKC (4) Polo-like Kinase (PLK) (3) Poly(ADP-ribose) Glycohydrolase (PARG) (2) Potassium Channel (2) PROTAC Linkers (1) PROTACs (1) RAD51 (1) Raf (1) Reactive Oxygen Species (ROS) (6) Reference Standards (13) RET (1) ROCK (2) RSV (1) SARS-CoV (14) Ser/Thr Protease (2) SHP2 (2) Sigma Receptor (1) Small Interfering RNA (siRNA) (4) Sodium Channel (12) SphK (2) STAT (2) STING (1) TAM Receptor (1) TGF-beta/Smad (1) TNF Receptor (4) Toll-like Receptor (TLR) (4) Topoisomerase (2) Transmembrane Glycoprotein (8) TREM receptor (1) Trk Receptor (1) TRP Channel (5) Tyrosinase (1) URAT1 (1) VEGFR (5) Virus Protease (6) Wee1 (1) Wnt (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (139) Cardiovascular Disease (13) Endocrinology (6) Infection (38) Inflammation/Immunology (136) Metabolic Disease (19) Neurological Disease (29)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	miRNA mimics (5) miRNA antagomirs (5) miRNA agomirs (5) Pegylated Lipids (1) MicroRNAs (20) Aptamers (2) Rat Pre-designed siRNA Sets (1) Phospholipids (1) Mouse Pre-designed siRNA Sets (1) miRNA inhibitors (5) Human Pre-designed siRNA Sets (2) siRNAs (4)

297

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

113

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108360

PDD 00017273 20+ Cited Publications	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC₅₀ of 26 nM, and a K_D of 1.45 nM .

HY-B0185

Lidocaine 20+ Cited Publications Lignocaine	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-17044

Duvelisib 15+ Cited Publications IPI-145; INK1197	PI3K	Cancer
Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC₅₀ of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively .

HY-P9930

Evolocumab 3 Publications Verification AMG 145	NF-κB Ser/Thr Protease Toll-like Receptor (TLR)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation .

HY-N0610A

Cinnamic acid 3 Publications Verification 3-Phenylacrylic acid; β-Phenylacrylic acid	Environmental Pollutants Endogenous Metabolite	Cancer
Cinnamic acid has potential use in cancer intervention, with IC₅₀s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-B0185A

Lidocaine hydrochloride 20+ Cited Publications Lignocaine hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .

HY-N0083

Betulin Maximum Cited Publications 15 Publications Verification Trochol	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite	Cancer
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line .

HY-103642A

D-myo-Inositol-1,4,5-triphosphate trisodium 1 Publications Verification Inositol 1,4,5-trisphosphate trisodium; Ins(1,4,5)-P3 trisodium	Calcium Channel	Metabolic Disease
D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.

HY-101507

Zerencotrep 10+ Cited Publications Pico145; HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of *TRPC1/4/5* channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-W017982

*CMIT/MIT (14.5% in water)* CMI/MI	Environmental Pollutants Bacterial Reactive Oxygen Species (ROS) p38 MAPK Mitochondrial Metabolism	Infection Neurological Disease Inflammation/Immunology
CMIT/MIT is a CMIT and MIT mixture. CMIT and MIT are powerful synthetic biocidal substances. CMIT and MIT are used as preservatives in various cosmetics and industrial products. CMIT and MIT are present in many water-soluble consumer products, such as shampoos, toothpastes. CMIT/MIT (3:1 mixture of CMIT and MIT) produces mitochondrial ROS via inhibiting mitochondrial complex I and II. CMIT/MIT (in 3:1 ratio) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. CMIT/MIT can be used in the research of respiratory diseases and neuroblastoma .

HY-150168

TH-Z145	Bacterial	Infection
TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 210 nM) .

HY-B0185B

Lidocaine hydrochloride hydrate 15+ Cited Publications Lignocaine hydrochloride hydrate	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-15755

RKI-1447 4 Publications Verification	ROCK	Cancer
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC₅₀ values of 14.5 nM and 6.2 nM, respectively.

HY-P990802

*Anti-Mouse CD3ε Antibody (145-2C11)*	CD3	Metabolic Disease Inflammation/Immunology
Anti-Mouse CD3ε Antibody (145-2C11) is an orally active anti-mouse CD3ε IgG1 monoclonal antibody. Anti-Mouse CD3ε Antibody (145-2C11) can inhibit the proliferation of effector T cells and improve the function of regulatory T cells (Tregs). Anti-Mouse CD3ε Antibody (145-2C11) relieves inflammatory response by inhibiting the production of pro-inflammatory cytokines and increasing the secretion of anti-inflammatory factors. Anti-Mouse CD3ε Antibody (145-2C11) can be used for researches on metabolic and immune system conditions such as diabetes and lupus. The recommend isotype control of Anti-Mouse CD3ε Antibody (145-2C11): Armenian hamster IgG, Isotype Control (HY-P990305) .

HY-107536

ML 145 1 Publications Verification	GPR35 CXCR	Inflammation/Immunology Endocrinology
ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC₅₀/EC₅₀ of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC₅₀/EC₅₀=21.7 μM) . ML 145 has no significant activity for GPR35 at either rodent ortholog .

HY-15779A

K145 hydrochloride 5+ Cited Publications	SphK Apoptosis	Cancer
K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC₅₀ of 4.3 μM and a K_i of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity .

HY-141514

MSA-2 dimer 1 Publications Verification	STING	Inflammation/Immunology Cancer
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .

HY-17044A

Duvelisib (R enantiomer) IPI-145 R enantiomer; INK1197 R enantiomer	PI3K	Cancer
Duvelisib R enantiomer is a PI3K inhibitor, which is the less active enantiomer of Duvelisib.

HY-B0185S1

Lidocaine-d10	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-16694

BAMB-4 1 Publications Verification ITPKA-IN-C14	Phosphatase	Cancer
BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC₅₀ value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer .

HY-P990284

*Anti-Mouse CD205 Antibody (NLDC-145)*	C-type Lectin-like Receptors (CTLRs)	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes .

HY-R00282

*hsa-miR-145-5p mimic*	MicroRNA	Cancer
hsa-miR-145-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-145-5p mimic hsa-miR-145-5p mimic

HY-N9686

Caffeoyl-CoA	Others	Others Inflammation/Immunology
Caffeoyl-CoA is a substrate of Chalcone synthase derived from rye with a K_m value of 1.45 μM .

HY-B0185AS

Lidocaine-d10 hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine-d₁₀ (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia .

HY-136975

Caspase-3-IN-1	Caspase	Neurological Disease Metabolic Disease
Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC₅₀ of 14.5 nM .

HY-B0185R

Lidocaine (Standard) 15+ Cited Publications Lignocaine (Standard)	Reference Standards Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine (Standard) is the analytical standard of Lidocaine. This product is intended for research and analytical applications. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-RI00282

*hsa-miR-145-5p inhibitor*	MicroRNA	Cancer
hsa-miR-145-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-145-5p inhibitor hsa-miR-145-5p inhibitor

HY-103642

D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt 1 Publications Verification Inositol 1,4,5-trisphosphate hexapotassium salt; Ins(1,4,5)-P3 hexapotassium salt	Calcium Channel	Metabolic Disease
D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is the hexapotassium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.

HY-133690

D-myo-Inositol-1,3,4,5-tetraphosphate sodium	Calcium Channel	Metabolic Disease
D-myo-Inositol-1,3,4,5-tetraphosphate sodium is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase.

HY-B0365AS

Memantine-d6 hydrochloride	Cytochrome P450 iGluR Autophagy	Neurological Disease
Memantine-d₆ (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with K_is of 0.51 nM and 94.9 μM, respectively .

HY-P99760

Nurulimab BCD-145	CTLA-4	Cancer
Nurulimab (BCD-145) is an anti-cytotoxic T lymphocyte antigen-4 (anti-CTLA-4) human monoclonal antibody. Nurulimab can be can be used in research of melanoma .

HY-17044R

Duvelisib (Standard) IPI-145 (Standard); INK1197 (Standard)	PI3K Reference Standards	Cancer
Duvelisib (Standard) is the analytical standard of Duvelisib. This product is intended for research and analytical applications. Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively .

HY-W795960

D-myo-Inositol 1,4,5-trisphosphate sodium salt	Biochemical Assay Reagents Calcium Channel Phospholipase	Neurological Disease Metabolic Disease
D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the *Ins (1,4,5) P₃* receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and Ca ²⁺-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

HY-B0185AS1

Lidocaine-d6 hydrochloride Lignocaine-d6 hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .

HY-105128

Epostane WIN 32729	3β-HSD	Endocrinology
Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC₅₀ of 1.45 nM. Epostane blocks ovulation and pregnancy in rats .

HY-N8331

Terpendole I	Endogenous Metabolite Acyltransferase	Metabolic Disease
Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism .

HY-15779

K145	SphK Apoptosis	Cancer
K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC₅₀ of 4.3 µM and a K_i of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity .

HY-R00281

*hsa-miR-145-3p mimic*	MicroRNA	Cancer
hsa-miR-145-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-145-3p mimic hsa-miR-145-3p mimic

HY-111389

FAAH-IN-1	FAAH Autophagy	Metabolic Disease
FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC₅₀s of 145 nM and 650 nM for rat and human FAAH, respectively.

HY-175243

ADAR1-IN-1	Adenosine Deaminase Apoptosis	Cancer
ADAR1-IN-1 is a potent ADAR1 inhibitor. ADAR1-IN-1 significantly suppressed DU-145 cell proliferation (IC₅₀ = 1.11 μM), clonogenicity, migration, and invasion, arrests cell cycle, and induces apoptosis. ADAR1-IN-1 safely and effectively inhibits tumor growth. ADAR1-IN-1 can be used for the study of prostate cancer (PCa) .

HY-P10345

OP-145	Bacterial	Infection
OP-145, an cathelicidin LL-37 derivative, is an antimicrobial peptide, and shows antibacterial activity against several MRSA strains. OP-145 can be used for research of chronic suppurative otitis media .

HY-122888

MPT0L145	PI3K FGFR Autophagy CDK Reactive Oxygen Species (ROS)	Cancer
MPT0L145 is a PIK3C3/FGFR inhibitor, with a K_d value of 0.53 nM for PIK3C3. MPT0L145 decreases the phosphorylation of FGFR1, FGFR3 and their downstream proteins (FRS2, ERK and Akt). MPT0L145 induces G0/G1 cell cycle arrest and decreased protein levels of cyclin E. MPT0L145 promotes mitochondrial dysfunction, ROS production, and DNA damage. MPT0L145 is an autophagy inhibitor. MPT0L145 significantly sensitizes cancer cells to targeted or chemotherapeutic agents. MPT0L145 can be used for cancer research, such as bladder cancer and NSCLC .

HY-160129

Centanamycin ML-970; AS-I-145; NSC 716970	Nucleoside Antimetabolite/Analog	Cancer
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI₅₀ of 34 nM in NCI-60 cell line screening .

HY-149415

Multi-kinase-IN-5	RET FGFR VEGFR c-Kit c-Met/HGFR PDGFR Raf	Cancer
Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC₅₀ of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively .

HY-P10992

YVPGP	PI3K Akt mTOR Caspase Apoptosis Bcl-2 Family	Cancer
YVPGP is an oligopeptide exacted from Anthopleura anjunae. YVPGP has a significant antitumor activity by mediating PI3K/AKT/mTOR signaling pathway. YVPGP arrests DU-145 cells in the S phase and induces apoptosis via mitochondrial and death receptor pathways (caspase3, 7, 8, 9). YVPGP effectively inhibits tumor growth in DU-145 xenografts mice model, promising for prostate cancer research .

HY-B0185S

Lidocaine-d10 N-Oxide	Isotope-Labeled Compounds Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-W037980

Succinamic acid	PROTAC Linkers	Metabolic Disease Cancer
Succinamic acid is a weak inhibitor for human LL-xylose reductase with an IC₅₀ of 1.45 mM. Succinamic acid can be used as a linker for synthesis of CQ-16 (HY-169336) .

HY-N15449

Vicanicin	HSP Caspase Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family	Cancer
Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer .

HY-B0185G

Lidocaine Lignocaine	Apoptosis Sodium Channel MEK ERK NF-κB	Cancer
Lidocaine (GMP) is Lidocaine (HY-B0185) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-171252

EGFR-IN-145	EGFR	Cancer
EGFR-IN-145 (compound 7c) is an EGFR kinase inhibitor. At a concentration of 20 μM, EGFR-IN-145 has an inhibition rate of 52.7% on EGFR-wild type kinase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6771

Cyclopiazonic acid 5+ Cited Publications	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Other Diseases Disease Research Fields Indole Alkaloids Source Classification	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-N0610A

Cinnamic acid 3 Publications Verification 3-Phenylacrylic acid; β-Phenylacrylic acid	Structural Classification Classification of Application Fields Simple Phenylpropanols Phenylpropanoids Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite
Cinnamic acid has potential use in cancer intervention, with IC₅₀s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-N0083

Betulin Maximum Cited Publications 15 Publications Verification Trochol	Triterpenes other families Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line .

HY-103312

Xestospongin C 5+ Cited Publications (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Animals Source Classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

HY-N1931

Epifriedelanol	Triterpenes Classification of Application Fields Anti-aging Terpenoids Plants Compositae Erythrina latissima E. Mey. Disease Research Fields Source Classification Cancer	Caspase PARP Apoptosis MDM-2/p53
Epifriedelanol is a triterpenoid found in the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells .

HY-N9686

Caffeoyl-CoA	Natural Products Gramineae Secale cereale Plants Source Classification	Others
Caffeoyl-CoA is a substrate of Chalcone synthase derived from rye with a K_m value of 1.45 μM .

HY-114457

Phosphatidylinositol 4,5-bisphosphate L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Lipid Source Classification	Phospholipase
Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABA_A receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema .

HY-N8331

Terpendole I	Alkaloids Structural Classification Microorganisms Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Indole Alkaloids Source Classification Cancer	Endogenous Metabolite Acyltransferase
Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism .

HY-N4157

Isopteropodine	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Rubiaceae Plants Source Classification	mAChR 5-HT Receptor Bacterial
Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

HY-N15449

Vicanicin	Natural Products Microorganisms Source Classification	HSP Caspase Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family
Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer .

HY-N0083R

Betulin (Standard) Trochol (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Endogenous metabolite Source Classification	Reference Standards Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite
Betulin (Standard) is the analytical standard of Betulin. This product is intended for research and analytical applications. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.

HY-N15710

Magnotriol B	Magnoliaceae Houpoea officinalis (Rehder & E. H. Wilson) N. H. Xia & C. Y. Wu Phenols Polyphenols Plants Source Classification	Cholinesterase (ChE)
Magnotriol B is a cholinesterase inhibitor with IC₅₀ values of 12.63 nM and 14.5 nM against AChE and BChE, respectively. Magnotriol B also exhibits significant NO inhibitory activity with an IC₅₀ of 2.02 μM. Magnotriol B can be used in the research of neurodegenerative and inflammatory diseases .

HY-N1252

Scillascillin	Phenols Polyphenols Plants Barnardia japonica (Thunberg) Schultes & J. H. Schultes Asparagaceae Juss. Source Classification	Others
Scillascillin (compound 10) is a homoisoflavanone. Scillascillin can be isolated from S. scilloides. Scillascillin shows anticancer activity towards MCF-7 (breast cancer) and DU-145 (prostate cancer) cells with the IC₅₀ of 9.59 and 11.32 ug/ml, respectively .

HY-130281

Ianthelliformisamine B diTFA	Natural Products Marine natural products Sponge Source Classification	Bacterial
Ianthelliformisamine B diTFA is a bromotyrosine-derived antibacterial agent. Ianthelliformisamine B diTFA is against E. coli and S. aureus strains with MICs of 14.5 μM and 144.7 μM .

HY-N0610AR

Cinnamic acid (Standard) 3-Phenylacrylic acid (Standard); β-Phenylacrylic acid (Standard)	Structural Classification Microorganisms Simple Phenylpropanols Phenylpropanoids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Cinnamic acid (Standard) is the analytical standard of Cinnamic acid. This product is intended for research and analytical applications. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-N4282

8-Hydroxy-7-methoxycoumarin	Structural Classification Classification of Application Fields Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Other Diseases Coumarins Phenylpropanoids Solanaceae Plants Disease Research Fields Source Classification	Others
8-Hydroxy-7-methoxycoumarin is a phenylpropanoid isolated from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. 8-Hydroxy-7-methoxycoumarin shows cytotoxicity against GLC4 and COLO 320 cancer cell after continuous incubation (4 days) with IC₅₀s of 179 μM and 145 μM .

HY-N8270

Physalin H	Cardiacglycosides Solanum nigrum Linn. Plants Solanaceae Steroids Source Classification	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N13174

Peanut procyanidin A	Arachis hypogaea L. Leguminosae Phenols Polyphenols Plants Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis .

HY-N12561

Pestanoid A	Microorganisms Terpenoids Diterpenoids Source Classification	ERK p38 MAPK JNK
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

HY-N12230

Penicolinate B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial Parasite Fungal
Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC₅₀: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC₅₀: 25.0 μg/mL), and activity against Candida albicans (IC₅₀: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .

HY-N4157R

Isopteropodine (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Rubiaceae Plants Source Classification	Reference Standards mAChR 5-HT Receptor Bacterial
Isopteropodine (Standard) is the analytical standard of Isopteropodine (HY-N4157). This product is intended for research and analytical applications. Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

HY-N10778

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol	Triterpenes Terpenoids Cucurbitaceae Plants Source Classification Momordica charantia Linn.	Others
(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .

HY-N17795

26-Hydroxyl-20(S)-protopanaxadiol	Structural Classification Natural Products Microorganisms Source Classification	Others
26-Hydroxyl-20(S)-protopanaxadiol is an inhibitor of prostate cancer cell proliferation, with an IC₅₀ value of 27.2 μM against human prostate cancer cells DU-145 and an IC₅₀ value of 18.5 μM against PC-3 cells .

HY-N15479

Nanangenine F	Microorganisms Terpenoids Sesquiterpenes Source Classification	Bacterial
Nanangenine F is a drimane sesquiterpenoid with weak antibacterial and anticancer activities. Nanangenine F inhibits Bacillus subtilis (ATCC 6633) with an IC₅₀ of 78 µg/mL. Nanangenine F inhibits NS-1, DU-145, MCF-7 and human fibroblast NFF cells with IC₅₀s of 49 µg/mL, 95 µg/mL, 49 µg/mL, and 84 µg/mL, respectively .

HY-N13896

Aureoquinone	Quinones Microorganisms Naphthalene Quinones Source Classification	Ser/Thr Protease
Aureoquinone is a broad-spectrum protease inhibitor. Aureoquinone inhibits trypsin, papain, thermophilic protease, collagenase and pound-protease, with IC₅₀ values of 11.4 μg/mL, 14.5 μg/mL, 17.8 μg/mL, 7.1 μg/mL, and 8.7 μg/mL, respectively .

HY-127083

Artecanin	Structural Classification Natural Products Laurus nobilis L. Plants Lauraceae Source Classification	SARS-CoV Virus Protease
Artecanin is a SARS-CoV-2 main protease (M ^pro) inhibitor with predicted high gastrointestinal absorption and oral bioavailability, and no predicted hepatotoxicity, carcinogenicity, mutagenicity or cytotoxicity. Artecanin interacts with His41 and Cys145, the key amino acid residues in the active site of M ^pro, blocks the cleavage and maturation of viral precursor proteins, and forms a stable complex with M ^pro. Artecanin blocks the invasion of SARS-CoV-2. Artecanin is applicable to the research of COVID-19 .

HY-N16691

Acrovestone	Structural Classification Ketones, Aldehydes, Acids Rutaceae Phenols Plants Acronychia pedunculata (L.) Miq. Source Classification	Others
Acrovestone (compound 4) is an Acronychia-type acetophenone dimer and a selective anticancer agent. Acrovestone has IC₅₀ values ??of 0.38 μM and 0.93 μM against A2058 melanoma cells and DU145 prostate cancer cells, respectively. Acrovestone shows low inhibitory activity against normal human dermal fibroblasts (NHDF), with an IC₅₀ >5 μM. Acrovestone can be used in anticancer research related to prostate cancer and melanoma. Acrovestone can be naturally extracted from the trunk bark of Acronychia pedunculata .

HY-N17297

Leotiomycene C	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Fungal
Leotiomycene C is an isoprenylated bisresorcinol natural product present in the freshwater fungus Helotiales sp. Leotiomycene C inhibits the quorum sensing system of methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA), with an IC₅₀ of 6.3-12.5 μM. Leotiomycene C is applicable to research related to MRSA infections .

Cat. No.	Product Name	Chemical Structure

HY-B0185S1

Lidocaine-d10

Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-B0185AS

Lidocaine-d10 hydrochloride

Lidocaine-d₁₀ (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia .

HY-B0365AS

Memantine-d6 hydrochloride
Memantine-d₆ (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with K_is of 0.51 nM and 94.9 μM, respectively .

HY-B0185AS1

Lidocaine-d6 hydrochloride

Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .

HY-N0610AS

Cinnamic acid-d6
Cinnamic acid-d₆ is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-N0610AS2

Cinnamic acid-13C3
Cinnamic acid- ¹³C₃ (3-Phenylacrylic acid- ¹³C₃) is the ¹³C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC₅₀s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .

HY-B0185S

Lidocaine-d10 N-Oxide

N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-B0185S2

Lidocaine-d6

Lidocaine-d₆ (Lignocaine-d₆) is deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-N0083S

Betulin-d3
Betulin-d₃ (Trochol-d₃) is deuterium labeled Betulin. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line .

HY-N0083S2

Betulin-d3-1
Betulin-d₃-1 is the deuterium labeled Betulin (HY-N0083). Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line.

HY-166909S

1,4,5-Trichloronaphthalene-13C10
1,4,5-Trichloronaphthalene- ¹³C₁₀ is ¹³C labeled 1,4,5-Trichloronaphthalene .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure