1449240-68-9
1449240-68-9
Chemical Structure
K145 hydrochloride
- CAS No.: 1449240-68-9
- Formula:C18H25ClN2O3S
- Molecular Weight:384.92
IUPAC Name: (Z)-3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride
InChIKey: HADFDMGQKBGVAV-NKBLJONXSA-N
SMILES: O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2.[H]Cl
Biological Activity: K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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K145 hydrochloride | 99.62% | K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-15779K145 -
Similarity Score 0.84
HY-183338SphK2-IN-4 -
Similarity Score 0.66
HY-113592ERK-IN-4 -
Similarity Score 0.54
HY-164290Rhodady C10 -
Similarity Score 0.53
HY-181757DCAF11 ligand-Linker Conjugate 1 -
Similarity Score 0.52
HY-151352DHDPS-IN-1 -
Similarity Score 0.52
HY-101947SMI-16a -
Similarity Score 0.51
HY-W838814ERK1/2 inhibitor 12 -
Similarity Score 0.50
HY-124863A(R)-AAL -
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