1945950-21-9
1945950-21-9
Chemical Structure
PDD 00017273
- CAS No.: 1945950-21-9
- Formula:C23H26N6O4S2
- Molecular Weight:514.62
IUPAC Name: 1-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
InChIKey: IFWUBRBMMNTBRZ-UHFFFAOYSA-N
SMILES: O=S(C1=CC2=C(N(CC3=CC(C)=NN3C)C(N(CC4=CN=C(C)S4)C2=O)=O)C=C1)(NC5(C)CC5)=O
Biological Activity: PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2].
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PDD 00017273 | 99.64% | PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM. | ||||||||||||||||||||
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PDD 00017273 (Standard) | ≥98% | PDD 00017273 (Standard) is the analytical standard of PDD 00017273 (HY-108360). This product is intended for research and analytical applications. PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a Kd of 1.45 nM. | ||||||||||||||||||||
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References
- [1]. James DI, et al. First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to AZD2281. ACS Chem Biol. 2016 Nov 18;11(11):3179-3190. Epub 2016 Oct 12. [Content Brief]
- [2]. Gravells P, et al. Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase. DNA Repair (Amst). 2017 Apr;52:81-91. [Content Brief]
Keywords
