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21

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (3) 17β-HSD (3) 5-HT Receptor (21) Acetyl-CoA Carboxylase (2) Ack1 (2) Acyltransferase (1) ADAMTS (1) ADC Linker (1) ADC Payload (7) Adenosine Deaminase (1) Adenosine Receptor (6) Adenylate Cyclase (2) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (10) Akt (25) Aldose Reductase (2) Amino Acid Derivatives (2) Aminoacyl-tRNA Synthetase (2) AMPK (8) Amylases (3) Amyloid-β (16) Anaplastic lymphoma kinase (ALK) (6) Androgen Receptor (4) Angiotensin Receptor (8) Antibiotic (39) Antibody-Drug Conjugates (ADCs) (1) AP-1 (4) Apelin Receptor (APJ) (2) Apoptosis (206) Arrestin (2) Aryl Hydrocarbon Receptor (4) ASK1 (1) Atg7 (1) Atg8/LC3 (2) ATM/ATR (2) ATP Citrate Lyase (1) ATP Synthase (1) ATP-binding cassette (ABC) transporters (1) Aurora Kinase (7) Autophagy (42) Bacterial (92) Bcl-2 Family (37) Bcr-Abl (8) Beta-lactamase (4) Beta-secretase (2) Biochemical Assay Reagents (116) BRK (1) Btk (5) c-Fms (4) c-Met/HGFR (9) c-Myc (10) C-type Lectin-like Receptors (CTLRs) (1) Calcium Channel (23) Calmodulin (2) CaMK (2) Cannabinoid Receptor (14) Carbonic Anhydrase (12) Carbonyl Reductase (1) Carboxylesterase (CES) (1) Casein Kinase (9) Caspase (28) CaSR (2) Cathepsin (3) CCR (2) CD20 (1) CD3 (3) CD73 (4) CD74 (1) CDK (62) CFTR (5) CGRP Receptor (2) Checkpoint Kinase (Chk) (2) Chloride Channel (2) Cholecystokinin Receptor (2) Cholinesterase (ChE) (34) CMV (2) Collagen (1) Complement System (9) COX (17) CRFR (6) CTLA-4 (1) Cuproptosis (2) CXCR (13) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (2) Cytochrome P450 (27) Dengue Virus (3) Deubiquitinase (11) DGK (1) Dihydrofolate reductase (DHFR) (1) Dihydroorotate Dehydrogenase (7) Dipeptidyl Peptidase (1) Discoidin Domain Receptor (3) DNA Alkylator/Crosslinker (4) DNA Methyltransferase (2) DNA Stain (1) DNA-PK (2) DNA/RNA Synthesis (47) Dopamine Receptor (15) Dopamine Transporter (1) Drug Derivative (39) Drug Intermediate (40) Drug Isomer (4) Drug Metabolite (7) Drug-Linker Conjugates for ADC (7) Dynamin (1) E1/E2/E3 Enzyme (12) E3 Ligase Ligand-Linker Conjugates (6) EAAT (2) Early 2 Factor (E2F) (2) EBV (2) EGFR (43) Elastase (7) ELOVL (1) Endogenous Metabolite (86) Endonuclease (1) Endothelin Receptor (5) Enolase (1) Enterovirus (6) Environmental Pollutants (8) Ephrin Receptor (4) Epigenetic Reader Domain (36) Epoxide Hydrolase (2) ERK (15) Estrogen Receptor/ERR (5) Eukaryotic Initiation Factor (eIF) (3) Exosomes (3) FAAH (3) FABP (1) Factor Xa (3) FAK (4) FAP (3) Farnesyl Transferase (2) FASTK (1) Fat Mass and Obesity-associated Protein (FTO) (3) Ferroptosis (10) FGFR (16) Filovirus (1) Flavivirus (3) FLT3 (10) Fluorescent Dye (13) Free Fatty Acid Receptor (1) Fungal (34) Furin (2) G protein-coupled Bile Acid Receptor 1 (1) G Protein-coupled Receptor Kinase (GRK) (1) G-quadruplex (2) GABA Receptor (22) Galectin (2) Gap Junction Protein (3) GCGR (1) GGTase (1) Gli (1) GLP Receptor (5) Glucocorticoid Receptor (52) GLUT (6) Glutathione Peroxidase (3) Glutathione S-transferase (1) Glycosidase (23) GnRH Receptor (4) GPR119 (1) GPR139 (1) GPR35 (2) GPR6 (1) GSK-3 (7) Guanylate Cyclase (2) HBV (1) HCN Channel (3) HCV (7) HCV Protease (4) HDAC (38) Hedgehog (3) Heme Oxygenase (HO) (2) Herbicide (5) HIF/HIF Prolyl-Hydroxylase (7) Histamine Receptor (9) Histone Acetyltransferase (7) Histone Demethylase (12) Histone Methyltransferase (23) HIV (19) HIV Integrase (2) HIV Protease (2) HPPD (1) HPV (2) HSP (18) HSV (5) IAP (5) ICMT (2) IFNAR (4) iGluR (11) IKK (5) IKZF Family (1) Imidazoline Receptor (2) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (12) Insecticide (11) Integrin (6) Interleukin Related (33) IRAK (7) Isocitrate Dehydrogenase (IDH) (2) Isotope-Labeled Compounds (132) JAK (10) JNK (17) Kallikrein (1) Keap1-Nrf2 (10) Ketohexokinase (1) Kinesin (1) KLF (1) Lactate Dehydrogenase (2) LAG-3 (1) LDLR (2) Leukotriene Receptor (2) Ligands for E3 Ligase (6) Ligands for Target Protein for PROTAC (5) Lipase (1) Liposome (3) Lipoxygenase (4) LPL Receptor (4) LRRK2 (2) LXR (1) LYTACs (1) mAChR (12) MAGL (4) MAP3K (6) MAP4K (11) MAPKAPK2 (MK2) (2) MARCKS (1) MDM-2/p53 (43) MEK (1) Melanocortin Receptor (3) MetAP (1) Methionine Adenosyltransferase (MAT) (2) mGluR (3) MicroRNA (32) Microtubule/Tubulin (19) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (12) Mitophagy (7) Mitosis (1) MMP (14) MNK (2) MOFs (158) Molecular Glues (10) Monoamine Oxidase (8) Monoamine Transporter (2) Mps1 (1) mRNA (4) mTOR (14) MyD88 (2) Myosin (1) N-myristoyltransferase (1) Na+/K+ ATPase (2) nAChR (7) NAMPT (1) Natriuretic Peptide Receptor (NPR) (1) Necroptosis (2) NEKs (3) Neuromedin U Receptor (NMUR) (1) Neuropeptide FF Receptor (1) Neuropeptide Y Receptor (2) NF-κB (37) NO Synthase (28) NOD-like Receptor (NLR) (11) Notch (7) NTPDase (4) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (14) Opioid Receptor (7) Orphan GPCR (1) P-glycoprotein (8) P-selectin (1) P2X Receptor (1) P2Y Receptor (2) p38 MAPK (24) PACAP Receptor (1) PAK (25) PANoptosis (1) Paraptosis (1) Parasite (42) PARP (25) PCSK9 (2) PD-1/PD-L1 (8) PDGFR (11) PDHK (2) PDK-1 (1) Penicillin-binding protein (PBP) (2) PERK (3) PGE synthase (3) Phosphatase (21) Phosphodiesterase (PDE) (17) Phospholipase (4) Phosphoramidites (1) Photosensitizer (1) PI3K (22) Piezo Channel (1) Pim (1) PIN1 (1) PINK1/Parkin (2) PKA (6) PKC (11) Platelet-activating Factor Receptor (PAFR) (2) Polo-like Kinase (PLK) (5) Potassium Channel (38) PPAR (23) Progesterone Receptor (1) Programmed Cell Death 4 (PDCD4) (2) Prostaglandin Receptor (11) PROTAC Linkers (17) PROTACs (41) Protease Activated Receptor (PAR) (2) Proteasome (6) Protein Arginine Deiminase (1) Proton Pump (1) Protoporphyrinogen IX oxidase (1) PSMA (1) PTEN (2) Pyroptosis (2) Pyruvate Kinase (1) RAD51 (1) Radionuclide-Drug Conjugates (RDCs) (2) Raf (5) RANKL/RANK (1) RAR/RXR (4) Ras (12) Reactive Oxygen Species (ROS) (43) Reference Standards (144) Renin (2) RET (5) REV-ERB (1) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (1) RIO Kinase (1) RIP kinase (5) ROCK (2) ROR (7) ROS Kinase (2) RSV (3) Salt-inducible Kinase (SIK) (2) SARS-CoV (33) Ser/Thr Kinase (2) Ser/Thr Protease (4) Serotonin Transporter (1) SGLT (2) SHMT (1) SHP2 (6) Sigma Receptor (6) Sirtuin (6) Small Interfering RNA (siRNA) (92) Smo (1) SOD (4) Sodium Channel (17) SOS1 (2) SphK (1) Src (7) SRPK (1) STAT (13) Stearoyl-CoA Desaturase (SCD) (2) STING (4) Succinate Dehydrogenase (2) SULT (1) Survivin (2) Syk (2) TAM Receptor (5) Target Protein Ligand-Linker Conjugates (3) Tau Protein (8) TGF-beta/Smad (14) TGF-β Receptor (6) Thrombin (5) Thymidylate Synthase (3) Thyroid Hormone Receptor (3) Tie (2) TMV (1) TNF Receptor (11) TNK1 (1) Toll-like Receptor (TLR) (19) Topoisomerase (12) Trace Amine-associated Receptor (TAAR) (1) Transmembrane Glycoprotein (2) Transthyretin (TTR) (1) Trk Receptor (8) TRP Channel (13) TrxR (1) TSH Receptor (1) Tyrosinase (9) URAT1 (2) Urease (1) VD/VDR (2) VEGFR (20) Virus Protease (15) VISTA (1) WDR5 (2) Wee1 (4) Wnt (14) Xanthine Oxidase (5) YAP (2) YB-1 (1) α-synuclein (1) β-catenin (8)
By Research Areas:	Cancer (883) Cardiovascular Disease (112) Endocrinology (79) Infection (268) Inflammation/Immunology (357) Metabolic Disease (207) Neurological Disease (294)
Click Chemistry:	Labeling and Fluorescence Imaging (1) PROTAC Synthesis (2) Azide (8) Alkynes (8)
Oligonucleotides:	miRNA mimics (9) miRNA antagomirs (5) saRNAs (1) Chemokine & Receptors (1) Rat Pre-designed siRNA Sets (18) miRNA inhibitors (5) mRNA (4) siRNA drugs (2) Other Phosphoramidite (1) Antisense Oligonucleotides (3) Cytidine (1) Cholesterol (1) siRNAs (93) miRNA agomirs (5) MicroRNAs (24) Nucleoside Analogs (10) Uridine (1) Cationic Lipids (2) Mouse Pre-designed siRNA Sets (17) Human Pre-designed siRNA Sets (56) Polymers (1) Phosphoramidites (1) Interleukin & Receptors (2)

2379

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

131

Peptides

MCE Kits

Inhibitory Antibodies

243

Natural
Products

214

Recombinant Proteins

147

Isotope-Labeled Compounds

206

Antibodies

Click Chemistry

140

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113405

21-Deoxycortisol	Endogenous Metabolite	Endocrinology
21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-113020

21-Hydroxypregnenolone 1 Publications Verification	Endogenous Metabolite Cytochrome P450	Metabolic Disease
21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM .

HY-107020

BMS 310705 21-Aminoepothilone B	Apoptosis	Cancer
BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B (HY-17029), targeting to malignancies such as ovarian, renal, bladder, and lung carcinoma. BMS 310705 induces significant apoptosis via mitochondrial-mediated pathway .

HY-100085

21-Desacetyldeflazacort 21-desDFZ	Drug Metabolite	Inflammation/Immunology
21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-W741510

21-Deoxy cortisone 21-Desoxycortisone; NSC 38722	Endogenous Metabolite	Cardiovascular Disease
21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is formed from 11-ketoprogesterone by the cytochrome P450 (CYP) isozyme CYP17A1, but can also be produced by oxidation of 21-deoxycortisone (HY-113405) by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Congenital adrenal hyperplasia is an inborn error of metabolism characterized by a deficiency of 21-hydroxylase, and 21-Deoxy Cortisone levels are elevated in patients with congenital adrenal hyperplasia.

HY-P991423

MEDI0639 21H3RK	Notch	Cancer
MEDI0639 (21H3RK) is a human monoclonal antibody (mAb) targeting DLL4. MEDI0639 inhibits Notch1 binding to Dll4. MEDI0639 reverses Notch1-mediated growth inhibition of human umbilical vein endothelial cells in vitro. MEDI0639 promotes human angiogenesis and reduces the number of vessels covered by smooth muscle actin-positive mural cells. MEDI0639 can be used in Small cell lung cancer and solid tumors research .

HY-W614724

21-Hydroxyhenicosanoic acid	Drug Derivative	Metabolic Disease
21-Hydroxyhenicosanoic acid is an ester product.

HY-N1086

Vinorine 21-Deoxyvomilenine	Others	Others
Vinorine is a compound isolated from the bark of Rauvolfia reflexa .

HY-W004464

2-(1-Piperazinyl)pyrimidine	Endogenous Metabolite	Neurological Disease
2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .

HY-W002896

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid	PROTAC Linkers	Cancer
2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W021675

2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid	PROTAC Linkers	Cancer
2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W140988

2-(1-benzylpiperidin-4-yl)ethan-1-amine	PROTAC Linkers	Cancer
2-(1-benzylpiperidin-4-yl)ethan-1-amine is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W329835S

2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5	Isotope-Labeled Compounds	Others
2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d₅ is the deuterium labeled 2-((1H-1,2,4-triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile .

HY-21059

2-(Pyridyl-2-yl)imidazole 2-(1H-Imidazol-2-yl)pyridine	MOFs	Others
2-(Pyridyl-2-yl)imidazole (2-(1H-Imidazol-2-yl)pyridine) is a metal-organic framework (MOF).

HY-113405R

21-Deoxycortisol (Standard)	Reference Standards Endogenous Metabolite	Endocrinology
21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol. This product is intended for research and analytical applications. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-134520

21-Deacetoxy deflazacort	Glucocorticoid Receptor	Inflammation/Immunology
21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant .

HY-N1690

21-epi-Serratenediol	Others	Others
21-epi-Serratenediol is a neutral triterpene isolated from Sitka spruce bark .

HY-135445

Prolylrapamycin 21-Norrapamycin	Fungal	Infection
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .

HY-136340

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione	Glucocorticoid Receptor NF-κB	Metabolic Disease Inflammation/Immunology
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization .

HY-W074957

2-(1-Benzylpiperidin-4-yl)acetic acid	PROTAC Linkers	Cancer
2-(1-Benzylpiperidin-4-yl)acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-20967

2-((1-(tert-Butoxycarbonyl)azetidin-3-yl)oxy)acetic acid	PROTAC Linkers	Cancer
2-((1-(tert-Butoxycarbonyl)azetidin-3-yl)oxy)acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W001371

2-(1-(Boc)Piperidin-4-yl)-2,2-difluoroacetic acid	PROTAC Linkers	Cancer
2-(1-(Boc)Piperidin-4-yl)-2,2-difluoroacetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-100085R

21-Desacetyldeflazacort (Standard) 21-desDFZ (Standard)	Drug Metabolite Reference Standards	Inflammation/Immunology
21-Desacetyldeflazacort (Standard) is the analytical standard of 21-Desacetyldeflazacort. This product is intended for research and analytical applications. 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-CE00809

21-Methylpentacosanoyl-CoA 21-Methylpentacosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
21-Methylpentacosanoyl-CoA (21-Methylpentacosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00823

21-Methyltricosanoyl-CoA 21-Methyltricosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
21-Methyltricosanoyl-CoA (21-Methyltricosanoyl-coenzyme A) is a coenzyme A derivative.

HY-CE00807

21-Methyldocosanoyl-CoA 21-Methyldocosanoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
21-Methyldocosanoyl-CoA (21-Methyldocosanoyl-coenzyme A) is a coenzyme A derivative.

HY-136602

MT-21	Apoptosis JNK Caspase	Cancer
MT-21 is an Apoptosis inducer and adenine nucleotide translocase inhibitor. MT-21 induces Apoptosis by activating JNK via the Krs/MST protein. MT-21 activates caspase-3 via caspase-9. MT-21 induces the release of cytochrome c. MT-21 can be used in the research of tumors .

HY-W759719

21-Desacetyldeflazacort-d4 21-desDFZ-d₄	Isotope-Labeled Compounds Drug Metabolite	Inflammation/Immunology
21-Desacetyldeflazacort-d₄ (21-desDFZ-d₄) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-100085S

21-Desacetyldeflazacort-d5 21-desDFZ-d₅	Glucocorticoid Receptor	Inflammation/Immunology
21-Desacetyldeflazacort-d₅ is the deuterium labeled 21-Desacetyldeflazacort .

HY-165967

21-Methyldocosanoic acid	Biochemical Assay Reagents	Metabolic Disease
21-Methyldocosanoic acid is an ester product.

HY-113405S1

21-Deoxycortisol-d8	Isotope-Labeled Compounds Endogenous Metabolite	Endocrinology
21-Deoxycortisol-d₈ is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-113020R

21-Hydroxypregnenolone (Standard)	Reference Standards Endogenous Metabolite Cytochrome P450	Metabolic Disease
21-Hydroxypregnenolone (Standard) is the analytical standard of 21-Hydroxypregnenolone (HY-113020). This product is intended for research and analytical applications. 21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM.

HY-W749323

21-Hydroxyeplerenone	Mineralocorticoid Receptor	Cardiovascular Disease
21-Hydroxyeplerenone is a major metabolite of the mineralocorticoid receptor antagonist Eplerenone (HY-B0251). 21-Hydroxyeplerenone is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4.

HY-113405S

21-Desoxycortisol-d4	Endogenous Metabolite Isotope-Labeled Compounds	Others
21-Desoxycortisol-d₄ is the deuterium labeled 21-Desoxycortisol .

HY-112541

21-Hydroxyoligomycin A	Ras Antibiotic	Cancer
21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC₅₀ value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces .

HY-134520R

21-Deacetoxy deflazacort (Standard)	Glucocorticoid Receptor Reference Standards	Inflammation/Immunology
21-Deacetoxy deflazacort (Standard) is the analytical standard of 21-Deacetoxy deflazacort. This product is intended for research and analytical applications. 21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant .

HY-N13115

21-Angeloyl-protoaescigenin (Z)-Protoescigenin 21-tiglate	Others	Cancer
21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively .

HY-W741017S

21-Desacetyl difluprednate-d6	Isotope-Labeled Compounds	Others
21-Desacetyl difluprednate-d₆ is deuterium-labeled 21-Desacetyl Difluprednate (HY-W741017) .

HY-N10385

Uvariol 21-Hydroxylanosterol	Others	Others
Uvariol (21-Hydroxylanosterol) is a natural product that can be isolated from the roots of Piptostigma fugax .

HY-N2275

21-O-Tigloylgymnemagenin	Others	Others
21-O-Tigloylgymnemagenin (Compound 7) is a acylated triterpenes isolated from Gymnema sylvestre .

HY-W740380

21-Carboxylic acid triamcinolone acetonide	Drug Metabolite	Others
21-Carboxylic acid triamcinolone acetonide is a metabolite produced in the body after oral administration of [14C]-triamcinolone acetonide .

HY-W742382

21-O-(1-Ethoxy)ethyl Cortisone-d9	Isotope-Labeled Compounds	Others
21-O-(1-Ethoxy)ethyl Cortisone-d₉ is the deuterium labeled 21-O-(1-Ethoxy)ethyl Cortisone.

HY-157585S

21-Dehydro Budesonide-d8-1	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology Cancer
21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies .

HY-N8616

21,23:24,25-Diepoxy-21,23-dimethoxytirucall-7-en-3-one	Others	Others
21,23:24,25-Diepoxy-21,23-dimethoxytirucall-7-en-3-one is a Triterpenoids product that can be isolated from the herbs of Amoora dasyclada .

HY-N1687

21,24-Epoxycycloartane-3,25-diol	Others	Others
21,24-Epoxycycloartane-3,25-diol (compound 15 or 16) is a cycloartanoid triterpene that can be isolated from the leaves of Lansium domesticum. 21,24-Epoxycycloartane-3,25-diol inhibits skin-tumor promotion .

HY-CE00024

(21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-CoA (21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-coenzyme A	Biochemical Assay Reagents	Others
(21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-CoA ((21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-CE00020

(21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-CoA (21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-coenzyme A; 3-Oxo-C36:5(omega-3)-coenzyme A	Biochemical Assay Reagents	Others
(21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-CoA ((21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-W741425

21-O-Acetyl dexamethasone 9,11-epoxide-d5	Isotope-Labeled Compounds	Others
21-O-Acetyl dexamethasone 9,11-epoxide-d₅ is the deuterium labeled 2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate (Dexamethasone Acetate Impurity) (HY-Z8003).

HY-167816

1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine 21:0 PC	Bacterial
1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine (21:0 PC) is a surfactant with antibacterial activity. 1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine can act in mucus to help prevent the spread of pathogens. 1,2-Diheneicosanoyl-sn-glycero-3-phosphocholine plays a protective role in biofilms, maintaining the health of organisms.

HY-W778716

2-(1-Ethoxyethylidene)malononitrile-13C2 Propanedinitrile, 2-(1-ethoxyethylidene)-¹³C₂; a-Cyano-b-methyl-b-ethoxyacrylonitrile-¹³C₂	Isotope-Labeled Compounds	Others
2-(1-Ethoxyethylidene)malononitrile- ¹³C₂ (Propanedinitrile, 2-(1-ethoxyethylidene)- ¹³C₂) is the ¹³C-labeled 2-(1-Ethoxyethylidene)malononitrile (HY-W008403).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15027

5-Aminosalicylic Acid 30+ Cited Publications Mesalamine; 5-ASA; Mesalazine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification Cancer	PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-101092

QS-21-Api 5+ Cited Publications Stimulon	Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NOD-like Receptor (NLR)
QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

HY-N0068

Solasodine 5 Publications Verification Purapuridine; Solancarpidine; Solasodin	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Solanum nigrum Linn. Solanaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis
Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities .

HY-B1183

Hydrocortisone acetate 1 Publications Verification Hydrocortisone 21-acetate; Cortisol 21-acetate	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids .

HY-17461A

Cortisone acetate 3 Publications Verification Cortisone 21-acetate	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Glucocorticoid Receptor Endogenous Metabolite
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-W015224

Methyl 2-(1H-indol-3-yl)acetate	Structural Classification Natural Products Classification of Application Fields Marine natural products Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Methyl 2-(1H-indol-3-yl)acetate is an indole ester.Methyl 2-(1H-indol-3-yl)acetate serves as a precursor for synthesis of S-alkylated/aralkylated 2-(1H-indol-3-ylmethyl)-1,3,4-oxadiazole-5-thiol derivatives .

HY-101092B

QS-21-Xyl	Structural Classification Quillajaceae Quillaja saponaria Molina Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Drug Intermediate
QS-21-Xyl is a active component of QS-21 (HY-101092A). QS-21 is a natural vaccine adjuvant and induces a balanced Th1/Th2 immune response, particularly cellular immunity .

HY-18061

Ochromycinone 3 Publications Verification (Rac)-STA-21	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Phenols Disease Research Fields Source Classification	Antibiotic STAT Bacterial
Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity .

HY-101092A

QS-21	Triterpenes Structural Classification Quillajaceae Quillaja saponaria Molina Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Toll-like Receptor (TLR)
QS-21 is a mixture of QS-21-Xyl (HY-101092B) and QS-21-Api (HY-101092), with a ratio of 35:65. QS-21 is an innate immune system-targeted adjuvant. QS-21 is promising for research of oncology vaccines (e.g., melanoma) and infectious disease vaccines (e.g., HIV, malaria) .

HY-113405

21-Deoxycortisol	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-113020

21-Hydroxypregnenolone 1 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Cytochrome P450
21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM .

HY-N8460A

Cortisol sulfate sodium 1 Publications Verification Cortisol 21-sulfate sodium	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate sodium is a specific ligand for intracellular transcortin .

HY-N16463

QS-S2	Triterpenes Structural Classification Quillajaceae Quillaja saponaria Molina Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Drug Intermediate
QS-S2 is the impurity of QS-21 (HY-101092A). QS-21 is an innate immune system-targeted adjuvant .

HY-N12763

Sodium new houttuyfonate SNH	Natural Products Saururaceae Houttuynia cordata Thunb. Plants Source Classification	Bacterial Renin
Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC₅₀ of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .

HY-10585B

*Valproic acid sodium (2:1)* Sodium Valproate (2:1); VPA sodium (2:1); 2-Propylpentanoic acid sodium (2:1)	Infection Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium (2:1) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

HY-N8460

Cortisol sulfate Cortisol 21-sulfate	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate is a specific ligand for intracellular transcortin .

HY-15027R

5-Aminosalicylic Acid (Standard) Mesalamine (Standard); 5-ASA (Standard); Mesalazine (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-N2102

Tenacissoside I	other families Classification of Application Fields Plants Disease Research Fields Steroids Cancer Source Classification	Others
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .

HY-N9320

13,21-Dihydroeurycomanone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants Disease Research Fields Source Classification	Parasite
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-N1086

Vinorine 21-Deoxyvomilenine	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Plants Indole Alkaloids Source Classification	Others
Vinorine is a compound isolated from the bark of Rauvolfia reflexa .

HY-W036553

6-Hydroxypyridin-2(1H)-one hydrochloride	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
6-Hydroxypyridin-2(1H)-one hydrochloride is an endogenous metabolite.

HY-W004464

2-(1-Piperazinyl)pyrimidine	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .

HY-113405R

21-Deoxycortisol (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol. This product is intended for research and analytical applications. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-N1690

21-epi-Serratenediol	Triterpenes Structural Classification Pinaceae Terpenoids Picea sitchensis (Bong.) Carrière Plants Pentacyclic Triterpenoids Source Classification	Others
21-epi-Serratenediol is a neutral triterpene isolated from Sitka spruce bark .

HY-135445

Prolylrapamycin 21-Norrapamycin	Natural Products Microorganisms Source Classification	Fungal
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-17461AR

Cortisone acetate (Standard) 3 Publications Verification Cortisone 21-acetate (Standard)	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Reference Standards Glucocorticoid Receptor Endogenous Metabolite
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .

HY-13434AR

Ionomycin calcium (Standard) SQ23377 calcium (Standard)	Structural Classification Microorganisms Antibiotics Disease Research Anticancer Other Antibiotics Source Classification	Reference Standards Calcium Channel PKC Bacterial Apoptosis Antibiotic
2-(1-Piperazinyl)pyrimidine (Standard) is the analytical standard of 2-(1-Piperazinyl)pyrimidine. This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .

HY-Z8245

20b-Dihydroprogesterone Progesterone EP impurity C	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Drug Derivative
20b-Dihydroprogesterone (Compond III) is a C-21 steroid found in water beetles Cybister limbatus, C. tripunctatus and C. confuses .

HY-N4328

Pasakbumin B 13α-(21)-Epoxyeurycomanone	Natural Products other families Eurycoma longifolia Jack Plants	Others
Pasakbumin B, a bioactive compound from Eurycoma longifolia Jack, exhibits potent antiulcer activity .

HY-N0582

Otophylloside B	Neurological Disease Classification of Application Fields Anti-aging Asclepiadaceae Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Source Classification	Amyloid-β
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .

HY-119759

Lipoxamycin	Infection Microorganisms Antifungal Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal
Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC₅₀ of 21 nM .

HY-N15846

VSA 1	Structural Classification Lipid	Drug Derivative
VSA 1, a semisynthetic QS-21 (HY-101092) analog, is a saponin adjuvant. VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection .

HY-113020R

21-Hydroxypregnenolone (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite Cytochrome P450
21-Hydroxypregnenolone (Standard) is the analytical standard of 21-Hydroxypregnenolone (HY-113020). This product is intended for research and analytical applications. 21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM.

HY-112541

21-Hydroxyoligomycin A	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Ras Antibiotic
21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC₅₀ value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces .

HY-N13115

21-Angeloyl-protoaescigenin (Z)-Protoescigenin 21-tiglate	Aesculus chinensis Bunge Triterpenes Terpenoids Hippocastanaceae Plants Source Classification	Others
21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively .

HY-N13115A

Protoescigenin 21-tiglate (E)-21-Angeloyl-protoaescigenin	Aesculus chinensis Bunge Triterpenes Terpenoids Hippocastanaceae Plants Source Classification	Others
Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively .

HY-N2275

21-O-Tigloylgymnemagenin	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Other Diseases Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification	Others
21-O-Tigloylgymnemagenin (Compound 7) is a acylated triterpenes isolated from Gymnema sylvestre .

HY-N7188

CJ-21,058	Natural Products Microorganisms Source Classification	Bacterial
CJ-21,058 is a potent SecA inhibitor with an IC₅₀ value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria .

HY-N8616

21,23:24,25-Diepoxy-21,23-dimethoxytirucall-7-en-3-one	Triterpenes Terpenoids Aglaia spectabilis (Miq.) S. S. Jain & Bennet Plants Meliaceae Source Classification	Others
21,23:24,25-Diepoxy-21,23-dimethoxytirucall-7-en-3-one is a Triterpenoids product that can be isolated from the herbs of Amoora dasyclada .

HY-N4162

3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker Cancer Source Classification	Others
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia .

HY-N10390

3β-Hydroxylanosta-8,24-dien-21-al	Triterpenes Structural Classification Tetracyclic Triterpenoids Microorganisms Terpenoids Source Classification	Others
3β-Hydroxylanosta-8,24-dien-21-al is a lanostane-type triterpene. 3β-Hydroxylanosta-8,24-dien-21-al can inhibit the tumor promotion, reducing the percentage of mice bearing papillomas .

HY-N13167

3-Keto-tirucall-8,24-dien-21-oic acid	Tetracyclic Triterpenoids Terpenoids Boswellia sacra Flück. Plants Burseraceae Source Classification	Reactive Oxygen Species (ROS)
3-Keto-tirucall-8,24-dien-21-oic acid is a tetracyclic triterpene compound that can be isolated from frankincense. 3-Keto-tirucall-8,24-dien-21-oic acid has activities like anti-inflammatory, anti-tumor, anti-ulcer, memory improvement, and antioxidant properties .

HY-N8460AR

Cortisol sulfate sodium (Standard) Cortisol 21-sulfate sodium (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate sodium is a specific ligand for intracellular transcortin .

HY-N1865

3-Oxotirucalla-7,24-dien-21-oic acid	Triterpenes Stereospermum acuminatissimum K.Schum. Terpenoids Bignoniaceae Plants Source Classification	Others
3-Oxotirucalla-7,24-dien-21-oic acid is a natural product, that can be isolated from Stereospermum acuminatissimum stem bark .

HY-N4035

Hop-17(21)-en-3-ol (3β)-A'-Neogammacer-17(21)-en-3-ol	Triterpenes Gentiana scabra Bunge Terpenoids Gentianaceae Plants Source Classification	Others
Hop-17(21)-en-3-ol ((3β)-A'-Neogammacer-17(21)-en-3-ol) is a Monoterpenoids product that can be isolated from the herbs of Xanthium sibiricum .

HY-N8800

3α-Hydroxytirucalla-7,24-dien-21-oic acid	Triterpenes Neurological Disease Classification of Application Fields Terpenoids Protium crenatum Sandwith Plants Burseraceae Disease Research Fields Source Classification	Others
3α-Hydroxytirucalla-7,24-dien-21-oic acid is a tirucallane triterpene isolated from the oleoresin of Protium hebetatum Daly .

HY-N1687

21,24-Epoxycycloartane-3,25-diol	Triterpenes Terpenoids Lansium domesticum Corrêa Plants Meliaceae Source Classification	Others
21,24-Epoxycycloartane-3,25-diol (compound 15 or 16) is a cycloartanoid triterpene that can be isolated from the leaves of Lansium domesticum. 21,24-Epoxycycloartane-3,25-diol inhibits skin-tumor promotion .

HY-18061R

Ochromycinone (Standard) (Rac)-STA-21 (Standard)	Quinones Monophenols Microorganisms Anthraquinones Phenols Source Classification	Antibiotic Reference Standards STAT Bacterial
Ochromycinone (Standard) ((Rac)-STA-21 (Standard)) is the analytical standard of Ochromycinone (HY-18061). This product is intended for research and analytical applications. Ochromycinone is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

HY-N13070

3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid	Triterpenes Microorganisms Terpenoids Source Classification	Others
3β-Acetoxy-5α-lanosta-8,24-dien-21-oic acid (compound 89) can be isolated from the secretions of the fungus Poria cocos (Schw.) .

Cat. No.	Product Name	Chemical Structure

HY-Y0172S

Butylated hydroxytoluene-d21
Butylated hydroxytoluene-d₂₁ is the deuterium labeled Butylated hydroxytoluene . Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products . Butylated hydroxytoluene is a Ferroptosis inhibitor .

HY-B1449S8

Uridine-d2-1
Uridine-d₂-1 is the deuterium labeled Uridine .

HY-15027S1

5-Aminosalicylic acid-d3
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-W749327

2,4-Di-tert-butylphenol-d21

2,4-Di-tert-butylphenol-d₂1 (2,4-DTBP-d₂1) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

HY-B0149S1

Tranexamic acid-d2-1
Tranexamic acid-d₂-1 is the deuterium labeled Tranexamic acid . Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC₅₀ of 5 mM .

HY-B0511S

Biotin-d2-1
Biotin-d₂-1 is the deuterium labeled Biotin. Biotin is an enzyme co-factor present in minute amounts in every living cell.

HY-N0473S10

L-Tyrosine-d2-1
L-Tyrosine-d₂-1 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-143704S

5-Aminosalicylic acid-13C6 hydrochloride
5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-W004282S

Undecanoic acid-d21
Undecanoic acid-d₂₁ (Undecanoate-d₂₁) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-W012351S

Tripropyl phosphate-d21
Tripropyl phosphate-d₂₁ is the deuterium labeled Tripropyl phosphate .

HY-163163S

18:1-21:2-18:1 TG-d5
18:1-21:2-18:1 TG-d5 is deuterium labeled 18:1-21:2-18:1 TG .

HY-W015224S

Methyl 2-(1H-indol-3-yl)acetate-d5
Methyl 2-(1H-indol-3-yl)acetate-d₅ is the deuterium labeled Methyl 2-(1H-indol-3-yl)acetate. Methyl 2-(1H-indol-3-yl)acetate is an endogenous metabolite.

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-N0210S11

D-Galactose-d2-1
D-Galactose-d₂-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.

HY-W329835S

2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5
2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d₅ is the deuterium labeled 2-((1H-1,2,4-triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile .

HY-I0960S6

Uracil-d2-1
Uracil-d₂-1 is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .

HY-141914S

Cortisol-21-glucuronide-d4 sodium
Cortisol-21-glucuronide-d₄ (sodium) is the deuterium labeled Cortisol-21-glucuronide .

HY-W009296S

Tri-p-tolylamine-d21
Tri-p-tolylamine-d₂₁ is the deuterium labeled Tri-p-tolylamine .

HY-13609S

Deflazacort-d5
Deflazacort-d₅ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-15027S4

5-Aminosalicylic acid-d7
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN) .

HY-W779002

alpha-D-glucose-13C2-1
alpha-D-glucose-13C2-1 is a ¹³C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite.

HY-W759719

21-Desacetyldeflazacort-d4

21-Desacetyldeflazacort-d₄ (21-desDFZ-d₄) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-100085S

21-Desacetyldeflazacort-d5
21-Desacetyldeflazacort-d₅ is the deuterium labeled 21-Desacetyldeflazacort .

HY-113405S1

21-Deoxycortisol-d8
21-Deoxycortisol-d₈ is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-W752483

Hydrocortisone 21-Acetate-d3
Hydrocortisone 21-Acetate-d₃ is the deuterium labeled Hydrocortisone 21-Acetate.

HY-113405S

21-Desoxycortisol-d4
21-Desoxycortisol-d₄ is the deuterium labeled 21-Desoxycortisol .

HY-13570CS

Betamethasone 21-phosphate-d5
Betamethasone 21-phosphate-d₅ is the deuterium labeled Betamethasone disodium phosphate. Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids .

HY-W741017S

21-Desacetyl difluprednate-d6
21-Desacetyl difluprednate-d₆ is deuterium-labeled 21-Desacetyl Difluprednate (HY-W741017) .

HY-142310S

Betamethasone 21-acetate 17-propionate-d3
Betamethasone 21-acetate 17-propionate-d₃ is the deuterium labeled Betamethasone 21-acetate 17-propionate .

HY-W099613S

1-Bromodecane-d21
1-Bromodecane-d₂₁ is the deuterium labeled 1-Bromodecane .

HY-W539998S

1-Decanethiol-d21
1-Decanethiol-d₂₁ is the deuterium labeled 1-Decanethiol .

HY-W654319

Tri-p-tolyl phosphate-d21
Tri-p-tolyl phosphate-d₂₁ is the deuterium labeled Tri-p-tolyl phosphate .

HY-143980S

Losartan impurity 21-d4

Losartan impurity 21-d₄ is the deuterium labeled Losartan impurity 21 . Losartan impurity 21-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W742382

21-O-(1-Ethoxy)ethyl Cortisone-d9
21-O-(1-Ethoxy)ethyl Cortisone-d₉ is the deuterium labeled 21-O-(1-Ethoxy)ethyl Cortisone.

HY-157585S

21-Dehydro Budesonide-d8-1
21-Dehydro Budesonide-d8-1 is deuterated labeled dehydrogenated Budesonide (HY-13580). Budesonide is an orally available glucocorticoid receptor agonist with anti-cancer activity. 21-Dehydro Budesonide-d8-1 acts as a probe for glucocorticoid receptors and is used in isotope tracing studies .

HY-W008630S

Decyltrimethylammonium-d21 bromide
N,N,N-Trimethyldecan-1-aminium-d₂₁ bromide is the deuterium labeled N,N,N-Trimethyldecan-1-aminium bromide .

HY-W742491

Betamethasone 21-Acetate-d3 17-Propionate
Betamethasone 21-Acetate-d₃ 17-Propionate is the deuterium labeled Betamethasone Dipropionate EP Impurity D (HY-148661).

HY-W745890

5b-Dihydrocortisol 21-O-(1-ethoxy ethyl) ether-d6
5b-Dihydrocortisol 21-O-(1-ethoxy ethyl) ether-d₆ is the deuterium labeled 5b-Dihydrocortisol 21-O-(1-ethoxy ethyl) ether.

HY-154743S

4-Pregnen-11β,21-diol-3,20-dione-d8
4-Pregnen-11β,21-diol-3,20-dione-d₈ is deuterated labeled 4-Pregnen-11β,21-diol-3,20-dione.

HY-B1214S

Prednisolone acetate-d8
Prednisolone acetate-d₈ is the deuterium labeled Prednisolone acetate. Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

HY-B1832S

Prednisone acetate-d3
Prednisone acetate-d₃ is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties .

HY-123489S

3α,21-Dihydroxy-5α-pregnan-20-one-d3
3α,21-Dihydroxy-5α-pregnan-20-one-d₃ is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

HY-W744577

Dexamethasone acetate-d5

Dexamethasone acetate-d₅ (Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-154774S

Tetrahydro-11-deoxy-Cortisol-d5-21-O-β-Glucuronide
Tetrahydro-11-deoxy-Cortisol-d₅-21-O-β-Glucuronide is deuterated labeled Tetrahydro-11-deoxy-Cortisol.

HY-13571S1

Betamethasone dipropionate-d5
Betamethasone dipropionate-d₅ (Betamethasone 17,21-dipropionate-d₅) is deuterium-labeled Betamethasone dipropionate (HY-13571) .

HY-W741425

21-O-Acetyl dexamethasone 9,11-epoxide-d5
21-O-Acetyl dexamethasone 9,11-epoxide-d₅ is the deuterium labeled 2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate (Dexamethasone Acetate Impurity) (HY-Z8003).

HY-W766835

Bisphenol A bissulfate-d6 disodium salt
Bisphenol A bissulfate-d₆ (disodium salt) (Sodium S,S′-[(1-methylethylidene)di-4,1-phenylene] disulfate-d₆ (2:1)) is the deuterium labeled Sodium S,S′-[(1-methylethylidene)di-4,1-phenylene] disulfate (2:1) (HY-W587516).

HY-W743132

Flumethasone-d3 Acetate
Flumethasone-d₃ Acetate is the deuterium labeled Flumethasone 21-acetate (HY-134115). Flumethasone 21-acetate (Compound 35) is a type of steroid. Flumethasone 21-acetate has lipophilic properties .

HY-141944S

Cortisol sulfate-d4 sodium
Cortisol-21-sulfate-d₄ (sodium) is the deuterium labeled Cortisol-21-sulfate .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1402G

Hydrocortisone hemisuccinate Hydrocortisone 21-hemisuccinate	Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) is a GMP-grade version of Hydrocortisone hemisuccinate (HY-B1402). GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers . .

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