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38691-95-1

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1 Results for "38691-95-1" in MCE Product Catalog:

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Groenlandicine
Groenlandicine
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Cat. No.: HY-N6865
CAS No.: 38691-95-1
Category:  

Ranunculaceae Metabolic Disease Plants Alkaloids Piperidine Alkaloids Monophenols Coptis chinensis Franch. Phenols Disease Research Fields Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) Topoisomerase Reactive Oxygen Species (ROS) Beta-secretase Apoptosis

Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC50 = 0.54 μM), BChE (IC50 = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 (IC50 = 19.68 μM, Ki = 21.2) and inhibits RLAR (IC50 = 140.1 μM), HRAR (IC50 = 154.2 μM), and total ROS generation (IC50 = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .
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