2 Results for "

Akt1-IN-6

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Akt1-IN-6" in MCE Product Catalog:

Akt1-IN-6
Akt1-IN-6
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Cat. No.: HY-163578
CAS No.: 3034254-12-8
Target:  

Akt

Research Areas:  

Cancer

Akt1-IN-6 (Compound 273) is an Akt1 inhibitor (IC50: <15 nM)
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2
Momordicine I
Momordicine I
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2 Cited Publications
Cat. No.: HY-122949
CAS No.: 91590-76-0
Purity:  ≥97.0%
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn.

Target:  

Oxidative Phosphorylation AMPK Keap1-Nrf2 Src Akt Apoptosis NO Synthase mTOR PI3K Autophagy Reactive Oxygen Species (ROS) Endogenous Metabolite Mitochondrial Metabolism NF-κB c-Met/HGFR DGK Interleukin Related STAT

Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes .
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