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Results for "

Angelica

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Akt (5) AMPK (1) Antibiotic (1) Apoptosis (8) Autophagy (1) Bacterial (9) Calcineurin (1) Calcium Channel (2) Caspase (1) Cholinesterase (ChE) (5) COX (3) Dopamine β-hydroxylase (1) Drug Metabolite (1) Endogenous Metabolite (2) ERK (4) FGFR (1) Fungal (1) Glutathione S-transferase (2) HIV (2) Integrin (2) Isotope-Labeled Compounds (3) JNK (2) Monoamine Oxidase (2) NF-κB (4) NO Synthase (3) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (2) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (5) PKC (4) Potassium Channel (2) PPAR (2) Reactive Oxygen Species (ROS) (1) Reference Standards (10) Sirtuin (2) STAT (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (17) Cardiovascular Disease (7) Endocrinology (1) Infection (10) Inflammation/Immunology (22) Metabolic Disease (7) Neurological Disease (10)

By Targets:

Acyltransferase (1)

Akt (5)

AMPK (1)

Antibiotic (1)

Apoptosis (8)

Autophagy (1)

Bacterial (9)

Calcineurin (1)

Calcium Channel (2)

Caspase (1)

Cholinesterase (ChE) (5)

COX (3)

Dopamine β-hydroxylase (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

ERK (4)

FGFR (1)

Fungal (1)

Glutathione S-transferase (2)

HIV (2)

Integrin (2)

Isotope-Labeled Compounds (3)

JNK (2)

Monoamine Oxidase (2)

NF-κB (4)

NO Synthase (3)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (2)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

PI3K (5)

PKC (4)

Potassium Channel (2)

PPAR (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (10)

Sirtuin (2)

STAT (2)

Toll-like Receptor (TLR) (2)

By Research Areas:

Cancer (17)

Cardiovascular Disease (7)

Endocrinology (1)

Infection (10)

Inflammation/Immunology (22)

Metabolic Disease (7)

Neurological Disease (10)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0708

Vanillic acid 2 Publications Verification	NF-κB Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects .

HY-N0548

*α-Angelica* lactone** 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-N0825

Nodakenin	Cholinesterase (ChE)	Inflammation/Immunology
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis	Neurological Disease Inflammation/Immunology
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-111588

Xanthoangelol 1 Publications Verification	Apoptosis Monoamine Oxidase Bacterial AMPK Caspase	Infection Inflammation/Immunology Cancer
Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells .

HY-N0286

Isoimperatorin Maximum Cited Publications 6 Publications Verification	Cholinesterase (ChE) Bacterial	Neurological Disease Cancer
Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC₅₀ of 74.6 μM.

HY-N0401

Ligustilide	Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects .

HY-N2488

Demethylsuberosin 4 Publications Verification 7-Demethylsuberosin	Calcium Channel NO Synthase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type Ca_V1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells .

HY-N0747

Oxypeucedanin	Potassium Channel PI3K NF-κB Akt p38 MAPK ERK COX NO Synthase JNK Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Oxypeucedanin is a furanocoumarin derivative found in Angelica dahurica. Oxypeucedanin is an orally active PI3K/AKT/NF-κB, MAPK, and ROS inhibitor. Oxypeucedanin induces cell cycle arrest and apoptosis. Oxypeucedanin inhibits hKv1.5 channel currents (IC₅₀: 76 nM). Oxypeucedanin exhibits anticancer, anti-inflammatory, antioxidant and antiarrhythmic activities .

HY-N2110

Phellopterin	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Inflammation/Immunology
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

HY-N2272

Cnidilin Knidilin	Others	Neurological Disease
Cnidilin (Knidilin) is isolated from the root of Angelica dahurica .

HY-N6022

Byakangelicin	Others	Metabolic Disease
Byakangelicin, one of the active compounds found in the roots of Angelica gigas, can serve as a modulator to improve brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhance therapeutic effects . Byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of agent-agent interactions. Byakangelicin can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones .

HY-W099617

2,3-Dihydroxypropyl decanoate 1-Decanoyl-rac-glycerol	Acyltransferase	Others
2,3-Dihydroxypropyl decanoate (1-Decanoyl-rac-glycerol) is a natural product that can be isolated from the root of Angelica dahurica .

HY-N0074

Byakangelicol 1 Publications Verification	COX	Inflammation/Immunology
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-N4273

Oxyimperatorin (±)-Heraclenin	Others	Others
Oxyimperatorin ((±)-Heraclenin) is a coumarin isolated from Angelica dahurica.

HY-N0947

(-)-Anomalin (-)-Praeruptorin B	Others	Inflammation/Immunology
(-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .

HY-N0075

(Rac)-Byakangelicin	Others	Metabolic Disease
(Rac)-Byakangelicin is a racemate of Byakangelicin mainly isolated from the genus Angelica. Byakangelicin is an aldose-reductase inhibitor with an IC₅₀ value of 6.2 μM .

HY-N2276

Nodakenetin	Others	Inflammation/Immunology
Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic .

HY-N0708R

Vanillic acid (Standard)	Reference Standards NF-κB Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Vanillic acid (Standard) is the analytical standard of Vanillic acid. This product is intended for research and analytical applications. Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects .

HY-W778225

Vanillic acid-13C6	Isotope-Labeled Compounds	Infection
Vanillic acid- ¹³C6 is the ¹³C labeled isotope of Vanillic acid- ¹³C6(HY-N0708 ).Vanillic acid is a flavoring agent found in edible plants and fruits, and in the root of angelica. Vanillic acid inhibits NF-κB activation. It has anti-inflammatory and antimicrobial activities.

HY-N2623

Alloimperatorin 1 Publications Verification Prangenidin	Others	Cancer
Alloimperatorin (Prangenidin), a coumarin compound, is extracted from Angelica dahurica. Alloimperatorin (Prangenidin) has antitumor activity .

HY-N0377A

(±)-Liquiritigenin (±)-4',7-Dihydroxyflavanone	Reactive Oxygen Species (ROS)	Cardiovascular Disease
(±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone) is isolated from Angelica keiskei, a hardy perennial herb of the Umbelliferae family. (±)-Liquiritigenin promotes cell proliferation, has cytoprotective activity and reduces cytotoxicity, and also has antioxidant stress effects .

HY-N0548R

*α-Angelica* lactone (Standard)**	Glutathione S-transferase Reference Standards	Cancer
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-W782599

Senkyunolide B	Fungal PKC Calcineurin	Infection
Senkyunolide B is a phthalide found in Angelica sinensis. Senkyunolide B has broad antifungal activities. Senkyunolide B affects the spore germination and hyphae growth of Aspergillus fumigatus via down-regulating phosphatidylinositol-PKC-calcineurin axis and the expression of ENG genes .

HY-N0401B

(E)-Ligustilide	Others	Metabolic Disease
(E)-Ligustilide is isolated from Angelica?sinensis and has nephroprotective?effects .

HY-N9507

Picrasidine Q	Apoptosis FGFR	Cancer
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity .

HY-N3524

Calycanthoside	Others	Inflammation/Immunology
Calycanthoside is a natural compound isolated from Angelica tenuissima .

HY-N4052

Heraclenol	Bacterial	Infection
Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities .

HY-126754

Archangelicin	Nuclear Factor of activated T Cells (NFAT) Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC₅₀ >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC₅₀ of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory .

HY-N7034

Magnolioside	Others	Neurological Disease
Magnolioside, isolated from Angelica gigas Nakai (Umbelliferae), exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-N4236

Angelol A	Others	Others
Angelol A is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model .

HY-N6892

3'-O-Acetylhamaudol 1 Publications Verification	Others	Cancer
3'-O-Acetylhamaudol, isolated from Angelica polymorpha, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation .

HY-N4235

Angelol B	Others	Inflammation/Immunology
Angelol B is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model .

HY-N13219

Angelica Extract	Others	Metabolic Disease
Angelica Extract is an angelica extract, and its components include: Ligustilide. Angelica Extract can effectively inhibit the differentiation of osteoclasts, regulate osteoclastogenesis and/or bone loss. Angelica Extract has the potential to be used in the study of various bone diseases caused by excessive bone resorption. .

HY-N0825R

Nodakenin (Standard)	Reference Standards Cholinesterase (ChE)	Inflammation/Immunology
Nodakenin (Standard) is the analytical standard of Nodakenin. This product is intended for research and analytical applications. Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

HY-W087444A

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol	Bacterial Antibiotic	Infection
(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is an active constituent of the aerial parts of Angelica sinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diol significantly inhibits the growth of Aeromonas hydrophila. Anticoagulative and antibiotic activities .

HY-N2110R

Phellopterin (Standard)	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

HY-N12069

Praeroside IV	Others	Inflammation/Immunology
Praeroside IV can be isolated from the roots of Angelica furcijuga. Praeroside IV can be used for research of D-GalN/LPS-induced liver injury .

HY-N1527

Quinovic acid 3-O-α-L-rhamnopyranoside Quinovic acid 3-O-α-L-rhamnoside	Others	Others
Quinovic acid 3-O-α-L-rhamnopyranoside (Quinovic acid 3-O-α-L-rhamnoside) is glycoside derivative. Quinovic acid 3-O-α-L-rhamnopyranoside can be isolated from the root bark of Guettarda angelica .

HY-N12070

11-O-β-D-glucopyranosyl thamnosmonin	Others	Cardiovascular Disease
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP .

HY-N9535A

(R)-tert-OMe-byakangelicin	Drug Metabolite	Metabolic Disease
(R)-tert-OMe-byakangelicin is a kind of furanocoumarin, which has inhibitory activity to liver drug metabolizing enzyme (DME) activity. (R)-tert-OMe-byakangelicin can be isolated from immature fruits of Angelica sinensis .

HY-N9364

Iso-oxypeucedanin	Others	Others
Iso-oxypeucedanin is a coumarin found in Angelica dahurica.

HY-N4234

Angelol K	Others	Inflammation/Immunology
Angelol K is a natural product from Chinese angelica.

HY-N4052A

(±)-Heraclenol	Bacterial	Infection
(±)-Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities .

HY-N15417

1,13-Tridecanolide	Others	Others
1,13-Tridecanolide is an odor compound that can be isolated from the angelica root .

HY-N1350

Riligustilide	Others	Others
Riligustilide (compound 2) is a kind of phthalide dimer. Riligustilide can be isolated from the radix of Angelica sinensis .

HY-N4273R

Oxyimperatorin (Standard) (±)-Heraclenin (Standard)	Reference Standards Others	Others
Oxyimperatorin (Standard) is the analytical standard of Oxyimperatorin. This product is intended for research and analytical applications. Oxyimperatorin ((±)-Heraclenin) is a coumarin isolated from Angelica dahurica.

HY-N0947R

(-)-Anomalin (Standard) (-)-Praeruptorin B (Standard)	Reference Standards Others	Inflammation/Immunology
(-)-Anomalin (Standard) is the analytical standard of (-)-Anomalin. This product is intended for research and analytical applications. (-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .

HY-N9532

Isobyakangelicol Anhydrobyakangelicin	Others	Cancer
Isobyakangelicol is a coumarin that can be found in the roots of Angelica dahurica. Isobyakangelicol inhibits the growth of HeLa and HepG2 cells, with IC₅₀s of 70.04 μM and 17.97 μM .

HY-N0286R

Isoimperatorin (Standard)	Reference Standards Cholinesterase (ChE) Bacterial	Neurological Disease Cancer
Isoimperatorin (Standard) is the analytical standard of Isoimperatorin. This product is intended for research and analytical applications. Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC₅₀ of 74.6 μM.

Cat. No.	Product Name	Category	Target	Chemical Structure