21422-04-8
Chemical Structure
Demethylsuberosin
Synonym(s): 7-Demethylsuberosin
- CAS No.: 21422-04-8
- Formula:C14H14O3
- Molecular Weight:230.26
IUPAC Name: 7-hydroxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
InChIKey: FIDUIAPDSKSUGO-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC(C/C=C(C)\C)=C(O)C=C2O1
Biological Activity: Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells[1][2][3].
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Demethylsuberosin | 99.71% | Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells. | ||||||||||||||||||||
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References
- [1]. Yongfen Ma, et al. Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells. J Food Sci Nutr Vol 14, p 179～187 (2009).
- [2]. Yang X, et al. Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel. J Ethnopharmacol. 2023 Sep 15;313:116527. [Content Brief]
- [3]. Kang SY, et al. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch Pharm Res. 2007 Nov;30(11):1368-73. [Content Brief]
