BL21

By Targets:	Adrenergic Receptor (1) Bacterial (6) Beta-lactamase (1) Biochemical Assay Reagents (4) Drug Intermediate (1) Endogenous Metabolite (2) Fluorescent Dye (2) Mitochondrial Metabolism (1) Renin (1) SARS-CoV (1) Transthyretin (TTR) (1) Virus Protease (1) β-glucuronidase (1)
By Research Areas:	Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W094510

Sodium pyrophosphate decahydrate	Biochemical Assay Reagents	Inflammation/Immunology
Sodium pyrophosphate decahydrate is a phosphate donor and mild chelating agent. Sodium pyrophosphate decahydrate serves as a phosphate source for Pseudomonas aeruginosa acid phosphatase and its Q6 variant, enabling phosphorylation of L‑ascorbic acid to L‑ascorbate‑2‑phosphate. Sodium pyrophosphate decahydrate facilitates ^99mTc labeling of human polyclonal IgG. Sodium pyrophosphate decahydrate can be used in research on musculoskeletal infections .

HY-155107

ND-011992	Mitochondrial Metabolism Bacterial	Infection
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo₃ oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21Δcyo* with the IC₅₀ of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study .

HY-B0952

2-Aminoheptane 1 Publications Verification Tuaminoheptane	Adrenergic Receptor	Neurological Disease
2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease .

HY-N2840

Allitol 1 Publications Verification Allodulcitol	Others	Metabolic Disease
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-147061

2-Deoxyribose 5-phosphate disodium	Biochemical Assay Reagents	Others
2-Deoxyribose 5-phosphate disodium is a substrate of 2-deoxyribose-5-phosphate aldolase (DERA). DERA belongs to class I aldolases, catalyzes reversible aldol reactions, and does not require any cofactors .

HY-N7389A

GDP-D-mannose disodium	Endogenous Metabolite Drug Intermediate	Metabolic Disease
GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a K_i value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a K_i value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG) .

HY-D2348

ACE	Fluorescent Dye	Infection Others
ACE is a low-background, photostable fluorophore with nanomolar binding affinity for the Okra RNA aptamer. ACE enables clear visualization of mRNA in live bacteria and mammalian cells, including tracking the trafficking of mRNA to stress granules and dual-color super-resolution imaging of RNA in live cells. (Ex=488 nm, Em=555 nm) .

HY-N12763

Sodium new houttuyfonate SNH	Bacterial Renin	Inflammation/Immunology
Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC₅₀ of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .

HY-D1460

Fluorescein Di-β-D-Glucuronide	Bacterial β-glucuronidase	Infection
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

HY-B2220B

Thermostable cellulase (recombinant)	Endogenous Metabolite	Others
Thermostable cellulase recombinant is a cellulose hydrolase present in hyperthermophiles, which catalyzes the hydrolysis of β-1,4 glycosidic bonds in cellulose. Thermostable cellulase recombinant targets carboxymethyl cellulose (CMC) as its primary substrate, and retains high residual activity even after incubation at high temperatures. The activity of Thermostable cellulase recombinant is inhibited by ionic and non-ionic detergents, and can be enhanced by cobalt ions. Thermostable cellulase recombinant can be applied in the paper industry .

HY-178019

NDM-1-IN-10	Beta-lactamase Bacterial	Infection
NDM-1-IN-10 (Compound CS-23) is an irreversible and covalent New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 36  nM. NDM-1-IN-10 shows a synergistic effect with Meropenem (HY-13678) against NDM-1-expressing E. coli ( MIC of 0.25 μg/mL for E. coli BL21/pET15b-bla_NDM-1). NDM-1-IN-10 can be used for bacterial infections research .

HY-151631

MRV03-070	Bacterial	Infection
MRV03-070 is an inhibitor of colibactin-activating peptidase ClbP with an IC₅₀ value of 69 nM, acts like biosynthetic precursor precolibactin .

HY-151626

MRV03-037	Bacterial	Infection
MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production .

HY-134429

p-Nitrophenyl α-L-arabinopyranoside	Biochemical Assay Reagents	Others
p-Nitrophenyl α-L-arabinopyranoside is a biochemical reagent. p-Nitrophenyl α-L-arabinopyranoside can be hydrolyzed by recombinant BgaA (rBgaA, isolated from E. coli BL21 (DE3) strain harboring pEBGA29). p-Nitrophenyl α-L-arabinopyranoside has potential application in enzyme activity detection .

HY-162474

BZG2	SARS-CoV Virus Protease	Infection
BZG2 is an allosteric inhibitor for the SARS-CoV-2 main protease (M ^pro), with an IC₅₀ of 77 µM .

HY-176233

Transthyretin-IN-4	Transthyretin (TTR)	Cardiovascular Disease
Transthyretin-IN-4 (Compound B26) is a bivalent inhibitor of transthyretin (TTR) amyloidosis (bIC₅₀: 0.09 µM, pIC₅₀: 1.4 µM). Transthyretin-IN-4 is used in the study of fatal heart failure with preserved ejection fraction (HFpEF) and fatal arrhythmias .

HY-P11790

EPEA tag peptide C-Tag peptide	Biochemical Assay Reagents	Infection
EPEA tag peptide (C-Tag peptide) is an epitope tag peptide. EPEA tag peptide enables elution of the SpaP ^EPEA complex. EPEA tag peptide is applicable to research related to bacterial type III secretion systems .

HY-D3416

TMR-DN TAMRA-2,4-dinitroaniline	Fluorescent Dye	Others
TMR-DN (TAMRA-2,4-dinitroaniline) is a bright orange fluorescent probe that binds to the SRB-2 aptamer, with a K_d value of 35 nM for the SRB-2 aptamer. TMR-DN exhibits low background fluorescence, enabling wash-free live-cell RNA imaging .

Cat. No.	Product Name	Type

HY-D2348

ACE	Fluorescent Dye
ACE is a low-background, photostable fluorophore with nanomolar binding affinity for the Okra RNA aptamer. ACE enables clear visualization of mRNA in live bacteria and mammalian cells, including tracking the trafficking of mRNA to stress granules and dual-color super-resolution imaging of RNA in live cells. (Ex=488 nm, Em=555 nm) .

HY-D1460

Fluorescein Di-β-D-Glucuronide	Fluorescent Dye
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

Fluorescein Di-β-D-Glucuronide

Fluorescent Dye

Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

HY-D3416

TMR-DN TAMRA-2,4-dinitroaniline	Fluorescent Dye
TMR-DN (TAMRA-2,4-dinitroaniline) is a bright orange fluorescent probe that binds to the SRB-2 aptamer, with a K_d value of 35 nM for the SRB-2 aptamer. TMR-DN exhibits low background fluorescence, enabling wash-free live-cell RNA imaging .

Cat. No.	Product Name	Type

HY-W094510

Sodium pyrophosphate decahydrate	Biochemical Assay Reagents
Sodium pyrophosphate decahydrate is a phosphate donor and mild chelating agent. Sodium pyrophosphate decahydrate serves as a phosphate source for Pseudomonas aeruginosa acid phosphatase and its Q6 variant, enabling phosphorylation of L‑ascorbic acid to L‑ascorbate‑2‑phosphate. Sodium pyrophosphate decahydrate facilitates ^99mTc labeling of human polyclonal IgG. Sodium pyrophosphate decahydrate can be used in research on musculoskeletal infections .

Sodium pyrophosphate decahydrate

Biochemical Assay Reagents

Sodium pyrophosphate decahydrate is a phosphate donor and mild chelating agent. Sodium pyrophosphate decahydrate serves as a phosphate source for Pseudomonas aeruginosa acid phosphatase and its Q6 variant, enabling phosphorylation of L‑ascorbic acid to L‑ascorbate‑2‑phosphate. Sodium pyrophosphate decahydrate facilitates ^99mTc labeling of human polyclonal IgG. Sodium pyrophosphate decahydrate can be used in research on musculoskeletal infections .

HY-134429

p-Nitrophenyl α-L-arabinopyranoside	Biochemical Assay Reagents
p-Nitrophenyl α-L-arabinopyranoside is a biochemical reagent. p-Nitrophenyl α-L-arabinopyranoside can be hydrolyzed by recombinant BgaA (rBgaA, isolated from E. coli BL21 (DE3) strain harboring pEBGA29). p-Nitrophenyl α-L-arabinopyranoside has potential application in enzyme activity detection .

Cat. No.	Product Name	Target	Research Area

HY-P11790

EPEA tag peptide C-Tag peptide	Biochemical Assay Reagents	Infection
EPEA tag peptide (C-Tag peptide) is an epitope tag peptide. EPEA tag peptide enables elution of the SpaP ^EPEA complex. EPEA tag peptide is applicable to research related to bacterial type III secretion systems .

Cat. No.	Product Name

HY-KE8013

Protein Deglycosylation Kit (for N-Linked & Simple O-Linked Glycans)
Protein Deglycosylation Kit (for N-Linked & Simple O-Linked Glycans) includes the enzymes and reagents necessary for the removal of all N-linked and relatively simple O-linked glycans. The enzymatic reagents are a mixture of three glycosidases, namely PNGase F, O-Glycosidase, and α2-3,6,8,9 Neuraminidase. All enzymes are recombinant enzymes expressed in Escherichia coli BL21 and subsequently purified. The molecular weights of these enzymes are as follows: PNGase F is 36 kDa, O-Glycosidase is 147 kDa, and α2-3,6,8,9 Neuraminidase is 66 kDa.

Protein Deglycosylation Kit (for N-Linked & Simple O-Linked Glycans)

Protein Deglycosylation Kit (for N-Linked & Simple O-Linked Glycans) includes the enzymes and reagents necessary for the removal of all N-linked and relatively simple O-linked glycans. The enzymatic reagents are a mixture of three glycosidases, namely PNGase F, O-Glycosidase, and α2-3,6,8,9 Neuraminidase. All enzymes are recombinant enzymes expressed in Escherichia coli BL21 and subsequently purified. The molecular weights of these enzymes are as follows: PNGase F is 36 kDa, O-Glycosidase is 147 kDa, and α2-3,6,8,9 Neuraminidase is 66 kDa.

HY-KE8014

Protein Deglycosylation Kit (for N-linked & Complex O-linked Glycans)
Protein Deglycosylation Kit (for N-linked & Complex O-linked Glycans) includes the enzymes and reagents reuired for the removal of all N-linked and some complex O-linked glycans. The enzyme reagent in this kit is a mixture of five glycosidases, namely PNGase F, O-Glycosidase, α2-3,6,8,9 Neuraminidase, β1-4 Galactosidase, and β-N-Acetylhexosaminidase. All enzymes in this kit are recombinant enzymes expressed in Escherichia coli BL21 and subsequently purified. The molecular weights of these enzymes are as follows: PNGase F is 36 kDa, O-Glycosidase is 14 kDa,α2-3,6,8,9 Neuraminidase is 66 kDa, β1-4 Galactosidase is 94 kDa, and β-N-Acetylhexosaminidase is 55 kDa.

Protein Deglycosylation Kit (for N-linked & Complex O-linked Glycans)

Protein Deglycosylation Kit (for N-linked & Complex O-linked Glycans) includes the enzymes and reagents reuired for the removal of all N-linked and some complex O-linked glycans. The enzyme reagent in this kit is a mixture of five glycosidases, namely PNGase F, O-Glycosidase, α2-3,6,8,9 Neuraminidase, β1-4 Galactosidase, and β-N-Acetylhexosaminidase. All enzymes in this kit are recombinant enzymes expressed in Escherichia coli BL21 and subsequently purified. The molecular weights of these enzymes are as follows: PNGase F is 36 kDa, O-Glycosidase is 14 kDa,α2-3,6,8,9 Neuraminidase is 66 kDa, β1-4 Galactosidase is 94 kDa, and β-N-Acetylhexosaminidase is 55 kDa.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2840

Allitol 1 Publications Verification Allodulcitol	Structural Classification Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Sweeteners Source Classification Food Research	Others
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-147061

2-Deoxyribose 5-phosphate disodium	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Biochemical Assay Reagents
2-Deoxyribose 5-phosphate disodium is a substrate of 2-deoxyribose-5-phosphate aldolase (DERA). DERA belongs to class I aldolases, catalyzes reversible aldol reactions, and does not require any cofactors .

HY-N7389A

GDP-D-mannose disodium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a K_i value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a K_i value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG) .

HY-N12763

Sodium new houttuyfonate SNH	Natural Products Saururaceae Houttuynia cordata Thunb. Plants Source Classification	Bacterial Renin
Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC₅₀ of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .

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