2. Metabolic Enzyme/Protease Anti-infection
  3. Mitochondrial Metabolism Bacterial
  4. ND-011992

ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study.

For research use only. We do not sell to patients.

ND-011992 Chemical Structure

ND-011992 Chemical Structure

CAS No. : 2446880-46-0

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ND-011992 Related Antibodies

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Description

ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].

IC50 & Target

0.12 μM (respiratory complex I), 2.47 μM (bo3 oxidase), 0.63 (bd-I oxidases), 1.3 μM (bd-II oxidases)
In Vitro

ND-011992 inhibits NADH oxidase activity of membranes from bovine heart mitochondria with an IC50 of 3.27 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ND-011992 Related Antibodies
Molecular Weight

381.35

Formula

C21H14F3N3O
CAS No.
SMILES

FC(F)(F)C(C=C1)=CC=C1OC(C=C2)=CC=C2NC3=NC=NC4=CC=CC=C43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ND-011992 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ND-0119922446880-46-0ND011992ND 011992Mitochondrial MetabolismBacterialTuberculosisMycobacterium tuberculosisrespiratory complex Ibo3 oxidasebd-I oxidasesbd-II oxidasesInhibitorinhibitorinhibit

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