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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
CYP oxidoreductase
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "CYP oxidoreductase" in MCE Product Catalog:
8
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Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment .
Cat. No.: HY-149769
CAS No.: 2227303-52-6
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CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .
Cat. No.: HY-W075315
CAS No.: 4329-78-6
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Xanthine oxidoreductase-IN-6 (Compound 4) is an orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 of 170 nM. Xanthine oxidoreductase-IN-6 can block the final step of uric acid biosynthesis and lower serum uric acid levels. Xanthine oxidoreductase-IN-6 also shows Cytochrome P450 3A4 (CYP3A4) inhibitory activity. Xanthine oxidoreductase-IN-6 can be used for the research of hyperuricemia .
Cat. No.: HY-149769A
CAS No.: 2227304-19-8
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CP-506 (compound 26) mesylate is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .
Cat. No.: HY-14874S
CAS No.: 2732868-49-2
Synonyms: FYX-051-d4
Cat. No.: HY-14874R
CAS No.: 577778-58-6
Synonyms: FYX-051 (Standard)
Research Areas:
Topiroxostat (Standard) is the analytical standard of Topiroxostat. This product is intended for research and analytical applications. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment .
Cat. No.: HY-E72104
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Human CYP3A5, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 3A5, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP3A5 is a human cytochrome P450 subtype belonging to the CYP3 family, which is predominantly expressed in human liver and intestine and metabolizes a variety of active compounds .
Cat. No.: HY-E72096
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Human CYP2B6, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 2B6, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2B6 is a human cytochrome P450 subtype belonging to the CYP2 family, and also serves as a minor but highly polymorphic hepatic metabolic enzyme that metabolizes various prodrugs or xenobiotics .
Cat. No.: HY-E72099
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Human CYP2C19, Reductase+b5 is a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 2C19, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2C19 is a human cytochrome P450 subtype belonging to the CYP2 family, as well as a major metabolic enzyme. It is predominantly expressed in the human liver and metabolizes various psychoactive compounds .
Cat. No.: HY-E72094
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Human CYP1A2, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 1A2, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP1A2 is a human cytochrome P450 subtype belonging to the CYP1 family, as well as a major metabolic enzyme. Its expression is centered in the human liver, and it can activate procarcinogens including aromatic heterocyclic amines and polycyclic aromatic hydrocarbons .
Cat. No.: HY-E72097
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Human CYP2C8, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2C8, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2C8 is a human cytochrome P450 subtype belonging to the CYP2 family, and also serves as a major metabolic enzyme. It is predominantly expressed in human liver and is capable of metabolizing a variety of active compounds .
Cat. No.: HY-E72098
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Human CYP2C9, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2C9, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2C9 is a human cytochrome P450 subtype belonging to the CYP2 family, and also a major metabolic enzyme. It is predominantly expressed in human liver and can metabolize a variety of active compounds .
Cat. No.: HY-E72102
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Human CYP3A4, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 3A4, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP3A4 is a human cytochrome P450 subtype belonging to the CYP3 family, as well as a major metabolic enzyme. It is predominantly expressed in human liver and intestine, metabolizes a variety of active compounds, and activates multiple procarcinogens .
Cat. No.: HY-E72101
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Human CYP2E1, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2E1, NADPH-P450 oxidoreductase (CPR), and cytochrome b5. Human CYP2E1 is a human cytochrome P450 subtype belonging to the CYP2 family, and also a major oxidase. Its expression is centered in human liver, and can be induced in the brain (neurons, astrocytes, cerebellar granule cells), lung and kidney .
Cat. No.: HY-E72095
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Human CYP2A6, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2A6, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2A6 is a human cytochrome P450 subtype belonging to the CYP2 family, as well as a major metabolic enzyme. It is predominantly expressed in human liver and metabolizes a variety of active compounds including Coumarin (HY-N0709) and nicotine .
Cat. No.: HY-E72103
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Human CYP1A1, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 1A1, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP1A1 is a human cytochrome P450 subtype belonging to the CYP1 family, as well as a major metabolic enzyme. Its expression is concentrated in tissues such as lung, breast, placenta and endometrium, and it can metabolize polycyclic aromatic hydrocarbons and estrogens into carcinogenic intermediates with DNA-damaging activity .
Cat. No.: HY-E72100
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Human CYP2D6, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 2D6, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP2D6 is a human cytochrome P450 subtype belonging to the CYP2 family, and also serves as a major metabolic enzyme capable of crossing the blood-brain barrier. Its expression is centered in the human liver (also detected in the brain) and exhibits high polymorphism .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
