577778-58-6
577778-58-6
Chemical Structure
Topiroxostat
Synonym(s): FYX-051
- CAS No.: 577778-58-6
- Formula:C13H8N6
- Molecular Weight:248.24
IUPAC Name: 4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)picolinonitrile
InChIKey: UBVZQGOVTLIHLH-UHFFFAOYSA-N
SMILES: N#CC1=NC=CC(C2=NNC(C3=CC=NC=C3)=N2)=C1
Biological Activity: Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].
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Topiroxostat | 99.06% | Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment. | ||||||||||||||||||||
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Topiroxostat (Standard) | ≥98% | Topiroxostat (Standard) is the analytical standard of Topiroxostat. This product is intended for research and analytical applications. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment. | ||||||||||||||||||||
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Topiroxostat-d4 | Topiroxostat-d4 is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.79
HY-W075315Xanthine oxidoreductase-IN-6 -
Similarity Score 0.75
HY-W5444494-(5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl)picolinonitrile -
Similarity Score 0.67
HY-W0752613,5-Di(pyridin-4-yl)-4H-1,2,4-triazol-4-amine -
Similarity Score 0.67
HY-W0748583,6-Di(pyridin-4-yl)-1,2,4,5-tetrazine -
Similarity Score 0.66
HY-W8561002-Methyl-4,6-di(pyridin-4-yl)-1,3,5-triazine -
Similarity Score 0.66
HY-W0899292-(3-(Pyridin-4-yl)-1H-1,2,4-triazol-5-yl)pyridine -
Similarity Score 0.65
HY-W2489944,4'-(1H-Pyrazole-3,5-diyl)dipyridine -
Similarity Score 0.65
HY-W4563033-Methyl-2-(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)pyridine -
Similarity Score 0.65
HY-W4563192-(5-(Pyridin-4-yl)-4H-1,2,4-triazol-3-yl)pyrazine -
Explore the MedChemAI to find more analogs
References
- [1]. Sato T, et al. Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected]. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9. [Content Brief]
- [2]. Matsumoto K, et al. FYX-051: a novel and potent hybrid-type inhibitor of xanthine oxidoreductase. J Pharmacol Exp Ther. 2011 Jan;336(1):95-103. [Content Brief]
