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Cat. No.: HY-E72101

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Human CYP2E1, Reductase+b5

Name: Human CYP2E1, Reductase+b5
Brand: MedChemExpress
SKU: HY-E72101
Price: 625.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Human CYP2E1, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, which consists of human cytochrome P450 2E1, NADPH-P450 oxidoreductase (CPR), and cytochrome b5. Human CYP2E1 is a human cytochrome P450 subtype belonging to the CYP2 family, and also a major oxidase. Its expression is centered in human liver, and can be induced in the brain (neurons, astrocytes, cerebellar granule cells), lung and kidney.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Human CYP2E1, Reductase+b5 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
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Calculators
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Biological Activity

Description

In Vivo

Human CYP2E1, Reductase+b5, via genetic suppression significantly ameliorates cerebral ischemia-reperfusion injury by reducing lesion volume (p < 0.005), neurological deficits, ROS production (1.5-fold reduction, p < 0.001), apoptosis, glial activation, inflammatory cytokine expression, and BBB leakage, while increasing protective 20-HETE levels by 41%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[Human CYP2E1, Reductase+b5]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu J, et al. Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury. Antioxidants (Basel, Switzerland). 2021 Jan 05;10(1):52. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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