Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
CYP450 3A4
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "CYP450 3A4" in MCE Product Catalog:
6
6 Cited Publications
Target:
Research Areas:
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth .
2
Cat. No.: HY-113482
CAS No.: 80434-32-8
Synonyms: 1β-OH-DCA
Target:
Cat. No.: HY-N6023
CAS No.: 19993-32-9
Cat. No.: HY-178479
CAS No.: 2581050-29-3
Research Areas:
IDO1-IN-30 (Compound (R)-100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions .
Cat. No.: HY-124527R
CAS No.: 339068-25-6
Target:
Research Areas:
HET0016 (Standard) is the analytical standard of HET0016. This product is intended for research and analytical applications. HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth .
Cat. No.: HY-178479A
Target:
Research Areas:
(Rac)-IDO1-IN-30 is the Rac isomer of IDO1-IN-30 (HY-178479). IDO1-IN-30 is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions .
Cat. No.: HY-188076
CAS No.: 375836-83-2
MBX2319 is an AcrB inhibitor and antibiotic efficacy restorer that potently inhibits RND-type efflux pumps of Enterobacteriaceae species. MBX2319 increases antibacterial activity of fluoroquinolone and β-lactam antibiotics against Escherichia coli, restores antibiotic efficacy, and reduces antibiotic MIC against Gram-negative bacteria. MBX2319 has no inherent antibacterial activity against Escherichia coli and does not alter bacterial outer membrane permeability. MBX2319 can be used for the research of gram-negative bacterial infections and multidrug-resistant gram-negative bacterial infections .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
