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Results for "

CoA biosynthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (3) HMG-CoA Reductase (HMGCR) (5) Autophagy (4) Biochemical Assay Reagents (6) Carnitine Palmitoyltransferase (CPT) (2) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (21) Environmental Pollutants (1) Glutathione Peroxidase (1) Herbicide (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) Nucleoside Antimetabolite/Analog (2) PANK (2) PROTAC Linkers (1) Reference Standards (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Infection (2) Metabolic Disease (24) Neurological Disease (3)

By Targets:

Acetyl-CoA Carboxylase (3)

HMG-CoA Reductase (HMGCR) (5)

Autophagy (4)

Biochemical Assay Reagents (6)

Carnitine Palmitoyltransferase (CPT) (2)

Drug Derivative (1)

Drug Intermediate (2)

Endogenous Metabolite (21)

Environmental Pollutants (1)

Glutathione Peroxidase (1)

Herbicide (1)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (2)

Nucleoside Antimetabolite/Analog (2)

PANK (2)

PROTAC Linkers (1)

Reference Standards (3)

By Research Areas:

Cancer (1)

Cardiovascular Disease (3)

Infection (2)

Metabolic Disease (24)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Stearoyl-CoA Desaturase (SCD) Acetyl-CoA synthetase HMG-CoA Reductase (HMGCR) Malonyl-CoA Decarboxylase SARS-CoV Acetyl-CoA Carboxylase Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141540

Lactyl-CoA 4 Publications Verification	Biochemical Assay Reagents Endogenous Metabolite	Others
Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers .

HY-137808

Succinyl-Coenzyme A sodium 3 Publications Verification Succinyl-CoA sodium	Endogenous Metabolite	Neurological Disease Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-134427

Palmitoyl coenzyme A lithium 2 Publications Verification Palmitoyl CoA lithium	Endogenous Metabolite	Metabolic Disease
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-W015924

2-Hydroxyisobutyric acid	Endogenous Metabolite	Metabolic Disease
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-E70009

Acyl-CoA oxidase ACO	Glutathione Peroxidase	Others
Acyl-CoA oxidase (ACO) is a peroxisomal catalyst. Acyl-CoA oxidase acts as a key rate-limiting enzyme in the process of peroxisomal fatty acid β-oxidation. Acyl-CoA oxidase participates in lipid catabolism and phytohormone biosynthesis pathways .

HY-44170

Pantothenate kinase-IN-2 2 Publications Verification	PANK	Neurological Disease Metabolic Disease
Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC₅₀ values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes .

HY-N7392A

Acetoacetyl-CoA sodium hydrate 3-Oxobutanoyl-coenzyme A sodium hydrate	Endogenous Metabolite	Metabolic Disease
Acetoacetyl CoA sodium hydrate is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA sodium hydrate from two acetyl-CoA molecules. Acetoacetyl CoA sodium hydrate is essential for cholesterol biosynthesis. Acetoacetyl-CoA sodium hydrate is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-B1189

Meglutol Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-Y1139

Pimelic acid 2 Publications Verification Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Endogenous Metabolite PROTAC Linkers	Metabolic Disease
Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .

HY-104051

Monacolin J Antibiotic MB 530A; Lovastatin diol lactone	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease
Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of *HMG-CoA* reductase**.

HY-N7392

Acetoacetyl-CoA 3-Oxobutanoyl-coenzyme A	Endogenous Metabolite	Metabolic Disease
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-137899

Dephospho-CoA 1 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction) .

HY-115899

Malonyl CoA Malonyl coenzyme A	Carnitine Palmitoyltransferase (CPT) Endogenous Metabolite Mitochondrial Metabolism	Metabolic Disease
Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 .

HY-N11658

p-Coumaroyl-CoA 4-Coumaroyl-CoA; p-coumaroylcoenzyme A	Biochemical Assay Reagents	Others
p-Coumaroyl-CoA (4-Coumaroyl-CoA; p-coumaroylcoenzyme A) is a coenzyme A derivative . p-Coumaroyl-CoA serves as a key intermediate in the biosynthesis of lignin and flavonoids .

HY-148285

Succinyl CoA Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A	Endogenous Metabolite	Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-114591

Spiromesifen BSN 2060	Environmental Pollutants Drug Derivative Acetyl-CoA Carboxylase	Infection
Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of *acetyl-CoA* carboxylase**, and has no cross-resistance to any resistant mite or whitefly populations .

HY-CE02017A

Feruloyl-CoA Feruloyl-coenzyme A	Drug Intermediate	Others
Feruloyl-CoA (Feruloyl-coenzyme A) is a cinnamoyl-CoA ester substrate involved in the biosynthesis of lignin and coumarin in plants. Feruloyl-CoA acts as a substrate for cinnamoyl-CoA reductase 1-dependent reduction reaction with NADPH to produce cinnamaldehyde. Feruloyl-CoA is a precursor that generates Scopoletin (HY-N0342) via spontaneous trans/cis isomerization and lactonization of its side chain .

HY-E70245

Cholyl-CoA Cholyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
Cholyl-CoA (Cholyl-coenzyme A) is a biologically active steroidal acyl-coenzyme A intermediate. Cholyl-CoA reacts with taurine in the presence of liver supernatant enzymes to promote the synthesis of taurocholic acid. Cholyl-CoA is formed by the activation of cholic acid with coenzyme A. Cholyl-CoA plays a key role in the biosynthesis, metabolism and conjugation reactions of bile acids .

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Endogenous Metabolite	Neurological Disease Metabolic Disease
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-W015924R

2-Hydroxyisobutyric acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-141473

Malonyl CoA tetralithium Malonyl coenzyme A tetralithium	Endogenous Metabolite Mitochondrial Metabolism Carnitine Palmitoyltransferase (CPT)	Metabolic Disease
Malonyl CoA (Malonyl coenzyme A) tetralithium is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA tetralithium is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 .

HY-142080

Pimeloyl-CoA Pimeloyl-coenzyme A	Endogenous Metabolite	Metabolic Disease
Pimeloyl-CoA is a key precursor compound in the biotin synthesis pathway, which can promote the de novo synthesis of biotin. Pimeloyl-CoA is mainly used in the study of microbial metabolic mechanisms, especially the analysis of biotin synthesis pathways and basic research on the biosynthesis of related antibiotics or vitamins .

HY-B1189S

Meglutol-d3 Dicrotalic acid-d₃; 3-Hydroxy-3-methylglutaric acid-d₃	Autophagy HMG-CoA Reductase (HMGCR) Endogenous Metabolite	Cardiovascular Disease
Meglutol-d₃ is the deuterium labeled Meglutol . Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.

HY-142080A

Pimeloyl-CoA lithium	Endogenous Metabolite	Metabolic Disease
Pimeloyl-CoA lithium is a biotin precursor of Escherichia coli. Pimeloyl-CoA lithium can be used for the research of the pathway of de novo biotin biosynthesis in Escherichia coli .

HY-148285A

Succinyl CoA disodium Succinyl-coenzyme A disodium; S-(Hydrogen succinyl)coenzyme A disodium	Endogenous Metabolite	Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-114591R

Spiromesifen (Standard) BSN 2060 (Standard)	Acetyl-CoA Carboxylase Reference Standards	Infection
Spiromesifen (Standard) is the analytical standard of Spiromesifen. Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of *acetyl-CoA* carboxylase**, and has no cross-resistance to any resistant mite or whitefly populations .

HY-113725

L 668411	HMG-CoA Reductase (HMGCR)	Others
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.

HY-B1189R

Meglutol (Standard) Dicrotalic acid (Standard); 3-Hydroxy-3-methylglutaric acid (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite Reference Standards	Cardiovascular Disease Metabolic Disease
Meglutol (Standard) is the analytical standard of Meglutol. This product is intended for research and analytical applications. Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-181917

Pantothenate kinase-IN-3	PANK	Metabolic Disease
Pantothenate kinase-IN-3 is an orally active PANK3-selective binder and *CoA* biosynthesis activator with a human PANK3 K_i of 9.1 nM, human PANK3 K_a of 1.8 nM, human PANK1β K_i of 113 nM, human PANK1β K_a of 23.4 nM, and oral effectiveness.Pantothenate kinase-IN-3 binds PANK3 via a water-mediated interaction between its sulfonamide NH and Gly193, elevates cellular, hepatic, and forebrain *CoA* levels, and shows improved metabolic stability in mouse and human microsomes.Pantothenate kinase-IN-3 has solubility properties favorable at pH 7.Pantothenate kinase-IN-3 can be used for the research of hepatic metabolic *CoA* deficiencies (acidemias) .

HY-141540S1

Lactyl-CoA-d3	Isotope-Labeled Compounds Biochemical Assay Reagents Endogenous Metabolite	Others
Lactyl-CoA-d₃ is the deuterium labeled Lactyl-CoA (HY-141540). Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers.

HY-180592

3α,7α-Dihydroxy-24-oxo-5β-cholestan-26-oyl-CoA	Nucleoside Antimetabolite/Analog	Metabolic Disease
3α,7α-Dihydroxy-24-oxo-5β-cholestan-26-oyl-CoA is a coenzyme A (CoA) ester is involved in bile acid biosynthesis .

HY-E70009A

Acyl-CoA oxidase, Arthrobacter sp.	Biochemical Assay Reagents	Metabolic Disease
Acyl-CoA oxidase, Arthrobacter sp. (EC 1.3.3.6) is a redox enzyme that acts on the CH-CH group in donor molecules and uses oxygen as an acceptor. Acyl-CoA oxidase, Arthrobacter sp. (EC 1.3.3.6) is involved in three metabolic pathways: fatty acid metabolism, polyunsaturated fatty acid biosynthesis, and the PPAR signaling pathway.

HY-185044

Galloyl-coenzyme A thioester	Drug Intermediate	Others
Galloyl-coenzyme A thioester is a CoA-thioester of Gallic acid (HY-N05230) that can be found in plants as an intermediate in gallotannin biosynthesis.Galloyl-coenzyme A thioester possesses spectral properties that support photometric assay use in enzymatic studies .

HY-CE01083

3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA 3α,7α,12α-Trihydroxy-24-oxo-5β-cholestan-26-oyl-CoA	Nucleoside Antimetabolite/Analog	Metabolic Disease
3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA (3α,7α,12α-Trihydroxy-24-oxo-5β-cholestan-26-oyl-CoA) is a coenzyme A ester for the study of β-oxidation in bile acid biosynthesis .

HY-113947

Metamifop	Herbicide Acetyl-CoA Carboxylase	Others
Metamifop is a post-emergence lipid synthesis inhibitor herbicide, with an IC₅₀ of 41.1 nM against the carboxyltransferase (CT) domain of chloroplast acetyl-CoA carboxylase (ACCase) in barnyard grass (Echinochloa crus-galli). Metamifop inhibits the activity of the CT domain, thereby blocking fatty acid biosynthesis .

HY-E71158

1,4-Dihydroxy-2-naphthoyl-CoA synthase	Biochemical Assay Reagents	Others
1,4-Dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) is involved in the synthesis of 1,4-Dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria) , phylloquinone (vitamin K1 in plants) , and many plant pigments.The coenzyme A group is subsequently removed from the product by EC 3.1.2.28, 1,4-Dihydroxy-2-naphthoyl-CoA hydrolase.

HY-134837

(3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid	Endogenous Metabolite	Others
(3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid (compound (25S)-3α,7α-dihydroxy-5β-cholestanoyl-CoA) is a Ursodeoxycholic Acid (HY-13771) precursor. (3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid is a key intermediary metabolite in the pathway of bile acid biosynthesis .

Cat. No.	Product Name

HY-L231

TCA Cycle Metabolite Compound Library	26 compounds
The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins. For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future. MCE supplies a unique collection of 26 key intermediates of the TCA cycle, which can be utilized for TCA-related research and metabolomics identification studies.

TCA Cycle Metabolite Compound Library

26 compounds

The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins.

For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future.

MCE supplies a unique collection of 26 key intermediates of the TCA cycle, which can be utilized for TCA-related research and metabolomics identification studies.

HY-L148

TCA Cycle Compound Library	72 compounds
The TCA cycle (tricarboxylic acid cycle)—is also known as the Krebs cycle or the citric acid cycle (CAC). The TCA cycle is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA in carbohydrates, fats, and proteins. For decades, the TCA cycle has been considered as the central pathway for cell oxidative phosphorylation to produce energy and biosynthesis. Research shows that TCA cycle is associated with many diseases, especially cancer. In colon carcinoma, liver cancer and other cancers, there are mutations that lead to the imbalance of TCA cycle metabolites, indicating that TCA cycle may be related to the occurrence of cancer. Understanding the role and molecular mechanism of TCA cycle in inhibiting or promoting cancer progression will promote the development of new metabolite-based cancer treatment methods in the future. MCE supplies a unique collection of 72 compounds related to the TCA cycle. MCE TCA Cycle Compound Library is a useful tool for the TCA cycle related research and anti-cancer drug development.

TCA Cycle Compound Library

72 compounds

MCE supplies a unique collection of 72 compounds related to the TCA cycle. MCE TCA Cycle Compound Library is a useful tool for the TCA cycle related research and anti-cancer drug development.

Cat. No.	Product Name	Type

HY-134427

Palmitoyl coenzyme A lithium 2 Publications Verification Palmitoyl CoA lithium	Biochemical Assay Reagents
Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .

HY-N7392

Acetoacetyl-CoA 3-Oxobutanoyl-coenzyme A	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-137808

Succinyl-Coenzyme A sodium 3 Publications Verification Succinyl-CoA sodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-W015924

2-Hydroxyisobutyric acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-N7392A

Acetoacetyl-CoA sodium hydrate 3-Oxobutanoyl-coenzyme A sodium hydrate	Alkaloids Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
Acetoacetyl CoA sodium hydrate is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA sodium hydrate from two acetyl-CoA molecules. Acetoacetyl CoA sodium hydrate is essential for cholesterol biosynthesis. Acetoacetyl-CoA sodium hydrate is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-B1189

Meglutol Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-Y1139

Pimelic acid 2 Publications Verification Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PROTAC Linkers
Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .

HY-N7392

Acetoacetyl-CoA 3-Oxobutanoyl-coenzyme A	Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-137899

Dephospho-CoA 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction) .

HY-115899

Malonyl CoA Malonyl coenzyme A	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Carnitine Palmitoyltransferase (CPT) Endogenous Metabolite Mitochondrial Metabolism
Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 .

HY-N11658

p-Coumaroyl-CoA 4-Coumaroyl-CoA; p-coumaroylcoenzyme A	Structural Classification Phenols Plants Source Classification	Biochemical Assay Reagents
p-Coumaroyl-CoA (4-Coumaroyl-CoA; p-coumaroylcoenzyme A) is a coenzyme A derivative . p-Coumaroyl-CoA serves as a key intermediate in the biosynthesis of lignin and flavonoids .

HY-148285

Succinyl CoA Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Other disease Disease markers Endogenous metabolite	Endogenous Metabolite
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-W015924R

2-Hydroxyisobutyric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-141473

Malonyl CoA tetralithium Malonyl coenzyme A tetralithium	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Mitochondrial Metabolism Carnitine Palmitoyltransferase (CPT)
Malonyl CoA (Malonyl coenzyme A) tetralithium is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA tetralithium is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1 .

HY-142080

Pimeloyl-CoA Pimeloyl-coenzyme A	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Endogenous Metabolite
Pimeloyl-CoA is a key precursor compound in the biotin synthesis pathway, which can promote the de novo synthesis of biotin. Pimeloyl-CoA is mainly used in the study of microbial metabolic mechanisms, especially the analysis of biotin synthesis pathways and basic research on the biosynthesis of related antibiotics or vitamins .

HY-B1189R

Meglutol (Standard) Dicrotalic acid (Standard); 3-Hydroxy-3-methylglutaric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite Reference Standards
Meglutol (Standard) is the analytical standard of Meglutol. This product is intended for research and analytical applications. Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-180592

3α,7α-Dihydroxy-24-oxo-5β-cholestan-26-oyl-CoA	Structural Classification Endogenous metabolite Steroids Source Classification	Nucleoside Antimetabolite/Analog
3α,7α-Dihydroxy-24-oxo-5β-cholestan-26-oyl-CoA is a coenzyme A (CoA) ester is involved in bile acid biosynthesis .

HY-CE01083

3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA 3α,7α,12α-Trihydroxy-24-oxo-5β-cholestan-26-oyl-CoA	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA (3α,7α,12α-Trihydroxy-24-oxo-5β-cholestan-26-oyl-CoA) is a coenzyme A ester for the study of β-oxidation in bile acid biosynthesis .

HY-134837

(3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid	Structural Classification Animals Steroids Source Classification	Endogenous Metabolite
(3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid (compound (25S)-3α,7α-dihydroxy-5β-cholestanoyl-CoA) is a Ursodeoxycholic Acid (HY-13771) precursor. (3α,5β,7α,25R)-3,7-Dihydroxycholestan-26-oic acid is a key intermediary metabolite in the pathway of bile acid biosynthesis .

Cat. No.	Product Name	Chemical Structure

HY-B1189S

Meglutol-d3
Meglutol-d₃ is the deuterium labeled Meglutol . Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.

HY-141540S1

Lactyl-CoA-d3
Lactyl-CoA-d₃ is the deuterium labeled Lactyl-CoA (HY-141540). Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers.

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