111-16-0
Chemical Structure
Pimelic acid
Synonym(s): Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid
- CAS. Nr.: 111-16-0
- Formula:C7H12O4
- Molecular Weight:160.17
IUPAC Name: heptanedioic acid
InChIKey: WLJVNTCWHIRURA-UHFFFAOYSA-N
SMILES: O=C(O)CCCCCC(O)=O
Biological Activity: Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism[1][2][3].
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Pimelic acid | 98.0% | Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism. | ||||||||||||||||||||
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Pimelic acid (Standard) | ≥98% | Pimelic acid (Standard) is the analytical standard of Pimelic acid. This product is intended for research and analytical applications. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research. | ||||||||||||||||||||
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- [1]. Li J X, et al. Pimelic acid‐based nucleating agents for hexagonal crystalline polypropylene[J]. Journal of Vinyl and Additive Technology, 1997, 3(2): 151-156.
- [2]. Manandhar M, et al. Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis. Mol Microbiol. 2017;104(4):595-607. [Content Brief]
- [3]. Yang Y, et al. Metabolic correlations between kidney and eye in a mouse model of oxygen-induced retinopathy and retinopathy of prematurity. BMJ Open Ophthalmol. 2025;10(1):e001955. Published 2025 May 1. [Content Brief]
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