Pimelic acid-13C2
Pimelic acid-13C2 (Heptanedioic acid-13C2) is the 13C-labeled Pimelic acid (HY-Y1139). Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism.
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- CAS No.: 78629-92-2
- Formule: C513C2H12O4
- Masse moléculaire:162.15
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 78629-92-2
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Unlabeled CAS 111-16-0
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Masse moléculaire 162.15
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Formule C513C2H12O4
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SMILES
O=[13C](O)CCCCC[13C](O)=O
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Synonyms
Heptanedioic acid-13C2; 1,5-Pentanedicarboxylic acid-13C2; 1,7-Heptanedioic acid--13C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[2]. Manandhar M, et al. Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis. Mol Microbiol. 2017;104(4):595-607. [Content Brief]
[3]. Yang Y, et al. Metabolic correlations between kidney and eye in a mouse model of oxygen-induced retinopathy and retinopathy of prematurity. BMJ Open Ophthalmol. 2025;10(1):e001955. Published 2025 May 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pimelic acid-13C2 Related Classifications
HY-Y1139S2 Related Classifications
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Keywords
- Pimelic acid-13C2
- 78629-92-2
- Heptanedioic acid-13C2
- 1,5-Pentanedicarboxylic acid-13C2
- 1,7-Heptanedioic acid--13C2
- Isotope-Labeled Compounds
- Endogenous Metabolite
- PROTAC Linkers
- biotin-requiring bacteria
- lipid metabolism
- fatty acid synthesis pathway
- biotin synthesis pathway
- Escherichia coli ΔbioC ΔbioH biotin auxotrophs
- oxygen-induced retinopathy
- Bacillus subtilis
- TCA cycle
- bioW-disrupted Bacillus subtilis strains
- fungi
- Inhibitor
- inhibitor
- inhibit