78629-92-2
78629-92-2
Chemical Structure
Pimelic acid-13C2
Synonym(s): Heptanedioic acid-13C2; 1,5-Pentanedicarboxylic acid-13C2; 1,7-Heptanedioic acid--13C2
- CAS No.: 78629-92-2
- Formula:C513C2H12O4
- Molecular Weight:162.15
InChIKey: WLJVNTCWHIRURA-AKZCFXPHSA-N
SMILES: O=[13C](O)CCCCC[13C](O)=O
Biological Activity: Pimelic acid-13C2 (Heptanedioic acid-13C2) is the 13C-labeled Pimelic acid (HY-Y1139). Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism[1][2][3].
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Pimelic acid-13C2 | Pimelic acid-13C2 (Heptanedioic acid-13C2) is the 13C-labeled Pimelic acid (HY-Y1139). Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism. | |||||||||||||||||||||
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Pimelic acid (Standard) | ≥98% | Pimelic acid (Standard) is the analytical standard of Pimelic acid. This product is intended for research and analytical applications. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research. | ||||||||||||||||||||
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Pimelic acid | 98.0% | Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism. | ||||||||||||||||||||
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Azelaic acid (Standard) | 99.80% | Azelaic acid (Standard) is the analytical standard of Azelaic acid. This product is intended for research and analytical applications. | ||||||||||||||||||||
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7-Methoxy-7-oxoheptanoic acid | 7-Methoxy-7-oxoheptanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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Glutaric acid | 98.44% | Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. | ||||||||||||||||||||
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Undecanedioic acid | 98.0% | Undecanedioic acid is an oral activie nndogenous metabolite. Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin. | ||||||||||||||||||||
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Decanedioic acid (Standard) | ≥98% | Decanedioic acid (Standard) is the analytical standard of Decanedioic acid (HY-W014787). This product is intended for research and analytical applications. Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency. | ||||||||||||||||||||
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Suberic acid | 98.0% | Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness. | ||||||||||||||||||||
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Adipic acid | 99.82% | Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-13C6 | 98.0% | Adipic acid-13C6 (Hexanedioic acid-13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-13C | 98.62% | Adipic acid-13C (Hexanedioic acid-13C) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | ||||||||||||||||||||
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Adipic acid-13C2 | Adipic acid-13C2 (Hexanedioic acid-13C2) is 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc. | |||||||||||||||||||||
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References
- [1]. Li J X, et al. Pimelic acid‐based nucleating agents for hexagonal crystalline polypropylene[J]. Journal of Vinyl and Additive Technology, 1997, 3(2): 151-156.
- [2]. Manandhar M, et al. Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis. Mol Microbiol. 2017;104(4):595-607. [Content Brief]
- [3]. Yang Y, et al. Metabolic correlations between kidney and eye in a mouse model of oxygen-induced retinopathy and retinopathy of prematurity. BMJ Open Ophthalmol. 2025;10(1):e001955. Published 2025 May 1. [Content Brief]
