1926-57-4
Chemical Structure
Lactyl-CoA
- CAS No.: 1926-57-4
- Formula:C24H40N7O18P3S
- Molecular Weight:839.60
IUPAC Name: S-(2-(3-((2R)-4-(((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) 2-hydroxypropanethioate
InChIKey: VIWKEBOLLIEAIL-FBMOWMAESA-N
SMILES: CC(O)C(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(O)(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1OP(O)(O)=O)=O)(O)=O)=O)=O)=O
Biological Activity: Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers[1][2].
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Lactyl-CoA | 94.32% | Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers. | ||||||||||||||||||||
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Lactyl-CoA-d3 | Lactyl-CoA-d3 is the deuterium labeled Lactyl-CoA (HY-141540). Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers. | |||||||||||||||||||||
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Similarity Score 1.00
HY-152953(R)-Lactoyl-CoA -
Similarity Score 0.95
HY-164094Isobutyryl-CoA -
Similarity Score 0.95
HY-CE01848S-[(2S)-3-Hydroxy-2-methylpropanoate]-CoA -
Similarity Score 0.94
HY-W7126753-Hydroxy-2-methylbutyryl-CoA -
Similarity Score 0.94
HY-114293Acetyl coenzyme A -
Similarity Score 0.94
HY-1414653-Hydroxybutyryl-CoA -
Similarity Score 0.94
HY-CE01302D-3-Hydroxybutyryl-CoA -
Similarity Score 0.94
HY-E702392-Methylbutyryl-CoA -
Similarity Score 0.94
HY-CE01673L-Threonine-CoA -
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References
- [1]. Liu R, et al. Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis. Cell Metab. 2025 Feb 4;37(2):377-394.e9. [Content Brief]
- [2]. Xiaoxia Zhang, et al. Screening, expression, purification and characterization of CoA-transferases for lactoyl-CoA generation. J Ind Microbiol Biotechnol. 2019 Jul;46(7):899-909. [Content Brief]