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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
218 Results for "
Cycloadiphene
" in MedChemExpress (MCE) Product Catalog:
Products (218)
218 Results for "Cycloadiphene" in MCE Product Catalog:
32
32 Publications Verification
Cat. No.: HY-P0023
CAS No.: 161552-03-0
32
32 Publications Verification
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
17
17 Cited Publications
Synonyms: Debio-025; DEB-025
Target:
Research Areas:
7
7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Research Areas:
4
4 Cited Publications
4
4 Cited Publications
4
4 Cited Publications
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3
3 Cited Publications
Cat. No.: HY-P0257
CAS No.: 170809-51-5
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Research Areas:
3
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2
2
2 Cited Publications
Category:
Vaccaria segetalis (Neck.) Garcke Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae
Target:
2
2 Cited Publications
Cat. No.: HY-P0231
CAS No.: 1088543-62-7
Target:
Research Areas:
2
2
1
Target:
Research Areas:
1
1 Cited Publications
Synonyms: Hexahydroadiphenine hydrochloride
Target:
Cholinesterase (ChE) Potassium Channel Amyloid-β TRP Channel Tau Protein NOD-like Receptor (NLR) JNK NF-κB IKK
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Drofenine (Cycloadiphene; Hexahydroadiphenine) hydrochloride is an brain-penetrant antispasmodic agent. Drofenine hydrochloride is a Kv2.1 channel inhibitor with human IC50 of 9.53 μM. Drofenine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with Ki of 0.003 mM, and is a TRPV3 activator. Drofenine hydrochloride blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial NLRP3 inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine hydrochloride induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine hydrochloride ameliorates diabetic peripheral neuropathy -like pathology. Drofenine hydrochloride can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm .
1
1
1 Cited Publications
Cat. No.: HY-P0031
CAS No.: 756500-23-9
1
1 Cited Publications
Cat. No.: HY-P1201
CAS No.: 84211-54-1
Target:
Research Areas:
1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
