204 Results for "

Cyclovirobuxine

" in MedChemExpress (MCE) Product Catalog:
Products (204)

204 Results for "Cyclovirobuxine" in MCE Product Catalog:

32
32 Publications Verification
Referencia número: HY-P0023
No. CAS: 161552-03-0
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
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32
32 Publications Verification
Referencia número: HY-P0023A
No. CAS: 500577-51-5
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
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17
17 Cited Publications
Referencia número: HY-12559
No. CAS: 254435-95-5
Pureza:  98.08%
Synonyms: Debio-025; DEB-025
Target:  

Cyclophilin HCV

Áreas de investigación:  

Infection

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
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7
7 Cited Publications
Referencia número: HY-P1934
No. CAS: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Áreas de investigación:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
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4
4 Cited Publications
Referencia número: HY-100563A
No. CAS: 217099-14-4
Pureza:  99.83%
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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4
4 Cited Publications
Referencia número: HY-100563
No. CAS: 250612-42-1
Pureza:  99.92%
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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4
4 Cited Publications
Referencia número: HY-12378
No. CAS: 136553-81-6
Pureza:  99.82%
Target:  

Endothelin Receptor

Áreas de investigación:  

Cardiovascular Disease

BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .
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3
3 Cited Publications
Referencia número: HY-P0257
No. CAS: 170809-51-5
Target:  

CRFR

Áreas de investigación:  

Neurological Disease

Astressin is a potent corticotropin releasing factor (CRF) antagonist.
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3
3 Cited Publications
Referencia número: HY-P1674A
No. CAS: 3053070-05-3
Synonyms: POL7080 TFA
Target:  

Bacterial Antibiotic

Áreas de investigación:  

Infection

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
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2
2 Cited Publications
Referencia número: HY-P2300
No. CAS: 862772-11-0
Synonyms: Cyclo(RGDfC)
Target:  

Integrin

Áreas de investigación:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
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2
2 Cited Publications
Referencia número: HY-107245
No. CAS: 164991-89-3
Pureza:  99.51%
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .
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2
2 Cited Publications
Referencia número: HY-P0231
No. CAS: 1088543-62-7
Target:  

GHSR

Áreas de investigación:  

Metabolic Disease Endocrinology

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
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2
2 Cited Publications
Referencia número: HY-P1676
No. CAS: 1975145-82-4
Synonyms: BK-1361
Target:  

MMP

Áreas de investigación:  

Cancer

cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer .
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2
2 Cited Publications
Referencia número: HY-P1676A
Synonyms: BK-1361 TFA
Target:  

MMP

Áreas de investigación:  

Cancer

cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer .
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1
1 Cited Publications
Referencia número: HY-N0107
No. CAS: 860-79-7
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR . Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis . Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction .
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1
1 Cited Publications
Referencia número: HY-P5712
No. CAS: 113-73-5
Synonyms: Gramicidin soviet
Áreas de investigación:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
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1
1 Cited Publications
Referencia número: HY-131109
No. CAS: 5845-66-9
Pureza:  99.70%
Target:  

Peptides

Áreas de investigación:  

Others

Cyclo(Gly-Tyr) is a cyclic dipeptide .
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1
1 Cited Publications
Referencia número: HY-P0031
No. CAS: 756500-23-9
Target:  

Integrin

Áreas de investigación:  

Others

Cyclo(RADfK) can be used as a control for Cyclo(-RGDfK) (HY-P0023) .
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1
1 Cited Publications
Referencia número: HY-P1201
No. CAS: 84211-54-1
Target:  

Somatostatin Receptor

Áreas de investigación:  

Cancer

Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells .
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1
1 Cited Publications
Referencia número: HY-P1682
No. CAS: 1051366-32-5
Synonyms: POL6326
Target:  

CXCR Arrestin

Áreas de investigación:  

Cancer

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
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