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Results for "

DCAF1 WDR domain

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
製品番号 製品名 Target 研究分野 構造式
  • HY-149935
    OICR-8268

    		Ligands for E3 Ligase Cancer
    OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can enable the development of DCAF1-based PROTACs .
    OICR-8268
  • HY-175343
    OICR-41103

    		Ligands for E3 Ligase Infection
    OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe that targets the DCAF1 WDR domain and replaces the viral Vpr protein. The binding Ki value of OICR-41103 and DCAF1 is less than 2 nM .
    OICR-41103
  • HY-175343A
    OICR-41103N

    		Ligands for E3 Ligase Infection
    OICR-41103N is the negative control form of OICR-41103 (HY-175343). OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe (Ki<2 nM) that targets the DCAF1 WDR domain and replaces the viral Vpr protein .
    OICR-41103N
  • HY-183988
    OICR409946

    		Ligands for E3 Ligase HIV Infection
    OICR409946 is a self-dimerization-induced proximity-targeting chimera (SDIPTAC) targeting DCAF1, with a Kd value of 6200 nM. OICR409946 binds to DCAF1, induces head-to-tail homodimerization, sterically blocks the Vpr binding interface, prevents the recruitment of Vpr to the CRL4DCAF1 complex, and inhibits Vpr-dependent HIV replication. OICR409946 can be used in studies related to HIV infection (DCAF1 ligand: (HY-169390); Linker: (HY-130659)) .
    OICR409946

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