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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
DNA exonuclease
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "DNA exonuclease" in MCE Product Catalog:
10
10 Cited Publications
Cat. No.: HY-19959
CAS No.: 1198097-97-0
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .
2
2 Cited Publications
Cat. No.: HY-W014622
CAS No.: 6960-45-8
Target:
Research Areas:
CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds .
Cat. No.: HY-W406070
CAS No.: 207131-16-6
Synonyms: LNA-G
Research Areas:
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. 2'-O,4'-C-Methyleneguanosine is a substrate for KOD DNA polymerase, which incorporates LNA-G nucleotides into growing DNA strands, including consecutive incorporations , to generate full-length extension products .
Cat. No.: HY-174143
CAS No.: 1111188-09-0
EXO1-IN-1 is a human exonuclease 1 (EXO1) inhibitor (IC50 = 15.7 μM). EXO1-IN-1 inhibits DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase polyamylation. EXO1-IN-1 induces apoptosis (Apoptosis) in BRCA1-deficient breast cancer cells. EXO1-IN-1 suppresses the growth of BRCA1-deficient breast cancer xenografts. EXO1-IN-1 can be used in research related to BRCA1-deficient breast cancer .
Cat. No.: HY-E70580
CAS No.: 2266626-22-4
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Research Areas:
T5 Exonuclease is a DNA exonuclease that has 5′-3′ exonuclease activity on both single- and double-stranded DNA. T5 Exonuclease also has single-strand endonuclease and 5′-flap endonuclease activity .
Cat. No.: HY-E70577
CAS No.: 63363-78-0
Target:
Research Areas:
DNA repair enzyme. Endonuclease IV has endonuclease activity at AP sites, 3' phosphodiesterase activity that can remove a variety of ligation-blocking lesions from the 3' end of DNA, endonuclease activity on oxidative DNA lesions, and 3' to 5' exonuclease activity .
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Research Areas:
Exonuclease III is a nuclease for specifically targeting double-stranded DNA (dsDNA). Exonuclease III is a DNA repair-associated nuclease with apurinic/apyrimidinic (AP)-endonuclease and 3'→5' exonuclease activities. Exonuclease III cleaves the ssDNA at 5'-bond of phosphodiester from 3' to 5' end by both exonuclease and endonuclease activities .
Cat. No.: HY-E70404
Research Areas:
FastTaq DNA Polymerase (5'→3' exo-) is a modified DNA polymerase based on Taq DNA Polymerase. FastTaq DNA Polymerase (5'→3' exo-) lacks the 5'→3' exonuclease activity of wild-type Taq. It retains the 5'→3' DNA polymerase activity of wild-type Taq .
Cat. No.: HY-P2937A
Target:
Research Areas:
DNA polymerase, NeoApollonia Thermophilus is a thermostable DNA polymerase from Streptococcus thermophilus that can be used in PCR reactions. DNA polymerase, NeoApollonia Thermophilus has 3’→5’ and 5’→3’ exonuclease activities.
Cat. No.: HY-E70904
Target:
Research Areas:
Terminal Transferase, Calf (EC 2.7.7.31) is a template independent polymerase that catalyzes the addition of deoxynucleotides to the 3' hydroxyl terminus of DNA molecules. Protruding, recessed or blunt-ended double or single-stranded DNA molecules serve as a substrate for Terminal Transferase. Terminal Transferase does not have 5' or 3' exonuclease activity. The addition of Co 2+ in the reacton makes tailing more efficient.
Cat. No.: HY-P704738
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WRN; WRN RecQ Like Helicase; RECQL2; RECQ3; Bifunctional 3'-5' exonuclease/ATP‑Dependent Helicase WRN; Werner Syndrome RecQ Like Helicase; DNA Helicase, RecQ‑Like Type 3; Werner Syndrome Protein; RecQ Protein‑Like 2; Werner Syndrome ATP‑Dependent Helicase
Species:
Human
Source:
E. coli
Cat. No.: HY-P85570
Synonyms: Cell cycle checkpoint control protein; Cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD 9; hRAD9; Rad 9; RAD 9A; RAD9; S pombe; homolog; RAD9 homolog A; RAD9 homolog; RAD9A; RAD9A_HUMAN.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
