6960-45-8
Chemical Structure
CRT0044876
- CAS No.: 6960-45-8
- Formula:C9H6N2O4
- Molecular Weight:206.16
IUPAC Name: 7-nitro-1H-indole-2-carboxylic acid
InChIKey: BIUCOFQROHIAEO-UHFFFAOYSA-N
SMILES: O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)O
Biological Activity: CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CRT0044876 | 98.44% | CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
