6960-45-8

CRT0044876 Chemical Structure
6960-45-8

Chemical Structure

CRT0044876

  • CAS No.: 6960-45-8
  • Formula:C9H6N2O4
  • Molecular Weight:206.16

IUPAC Name: 7-nitro-1H-indole-2-carboxylic acid

InChIKey: BIUCOFQROHIAEO-UHFFFAOYSA-N

SMILES: O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)O

Biological Activity: CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds[1].

Cat. No. Product Name Purity Description Pricing
HY-W014622 		CRT0044876 98.44% CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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