1 Result for "

Degalactotigonin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Degalactotigonin" in MCE Product Catalog:

Degalactotigonin
Degalactotigonin
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Cat. No.: HY-N9684
CAS No.: 39941-51-0
Category:  

Plantaginaceae Digitalis purpurea L. Natural Products Plants

Target:  

EGFR GSK-3 Hedgehog Akt ERK Apoptosis

Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma .
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